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Can a gel boost gum grafts? new study tests hyaluronic acid for receding gums

NCT ID NCT07291583

Disease control Sponsor: Saglik Bilimleri Universitesi Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study looks at whether adding hyaluronic acid (a natural gel) to standard gum graft surgery helps cover exposed tooth roots better and improves healing. Forty adults with receding gums will be randomly assigned to get the graft alone or with the gel. The main goal is to measure how much root coverage is achieved after 6 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jul 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 months and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presence of at least one gingival recession defect classified as Cairo RT1 or Miller Class I-II with a minimum depth of 1 mm. * Full-mouth plaque score (FMPS) and full-mouth bleeding on probing (FMBOP) \< 15%. * Detectable cemento-enamel junction (CEJ). * Age ≥ 18 years. * No history of prior periodontal surgical treatment. * Sufficient mental capacity to understand the study aims and procedures explained verbally and in writing. * Determined to be cooperative and compliant with the clinician before, during, and after the surgical procedure. Exclusion Criteria: * Patients younger than 18 years. * Periodontally healthy individuals. * Current smokers. * History of periodontal treatment within the past 1 year. * Use of antibiotics within the past 3 months. * Pregnancy or breastfeeding. * Presence of systemic diseases such as diabetes, chronic kidney failure, cancer, bleeding disorders, connective tissue diseases, or other chronic conditions; and gingival recessions classified as Cairo RT3. * Presence of cervical caries or restorations at the defect site.

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Conditions

The condition(s) this trial relates to.

gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession

Contacts and locations

Locations

  • University of Health Sciences, Gülhane Faculty of Dentistry

    Ankara, None Selected, 6220, Turkey (Türkiye)

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