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Bovine bone graft vs. natural healing: which rebuilds jawbone better?

NCT ID NCT06749158

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at two ways to help jawbone heal after a cyst is removed. One group received a graft made from cow bone to guide new bone growth, while the other group let the bone heal on its own. The goal was to see which method leads to denser and more bone in the defect. 44 adults with jaw cysts took part, and the results were measured with CT scans and tissue analysis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Started

Dec 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Presence of a well-defined pathological cystic lesion involving the maxilla, confirmed clinically and radiographically that require surgical enucleation resulting in an intra-bony defect. 2. Mesiodistal dimension of the defect ranging from 1 cm to 4.0 cm. 3. Patients aged 20 to 50 years, of either sex. 4. Patients medically fit for surgical intervention under local or general anesthesia (ASA I or II) 5. Absence of systemic conditions affecting bone healing (e.g., uncontrolled diabetes, osteoporosis) 6. Patients willing to participate in the study and able to provide informed written consent. 7. Availability of adequate postoperative follow-up (minimum of 6 months). Exclusion Criteria: 1. Pregnant or lactating women. 2. Radiographically, Presence of multi-locular or aggressive lesions suggestive of odontogenic tumors (e.g., ameloblastoma) 3. Patients with compromised immune status (e.g., HIV, long-term corticosteroid therapy) 4. History of allergic reaction to any of the surgical materials used (e.g., titanium, bovine bone graft). 5. Patients participating in another clinical trial or receiving investigational therapy during the study period. 6. Presence of acute infection at the surgical site. 7. cysts with a known high recurrence rate such as Odontogenic keratocysts (OKC).

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Conditions

The condition(s) this trial relates to.

odontogenic cyst

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Maxillary cyst

Contacts and locations

Locations

  • faculty of oral and dental medicine, Cairo university

    Cairo, Giza Governorate, 12613, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.