Green tea cream shows promise for rare 'Fish Scale' skin disease
NCT ID NCT01222000
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a cream made from green tea extract (Veregen) on 6 people with lamellar ichthyosis, a rare genetic condition that causes severe dry, scaly skin. Participants applied the cream to one side of their body and a standard moisturizer to the other for 4 weeks. The goal was to see if the green tea cream could improve skin scaling and roughness better than moisturizer alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- green tea extract (epigallocatechin-3-gallate) cream
- What this could lead to
- If it works, this could point toward a new topical treatment to ease skin scaling and roughness in lamellar ichthyosis.
- What could go wrong
- This is a very small pilot study with only 6 participants, so results may not apply to everyone. The treatment is tested on just one side of the body, and it may not work or may cause skin irritation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
6 people
The number who actually took part.
- Started
-
Oct 2010
- Finished
-
Mar 2013
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
8 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients of both sexes of at least 8 years and less than 65 years. * Patients with a clinical diagnosis of LI * Patients having at once a score of roughness and a desquamation of intensity moderated in severe (at least 2) on every side of the body, * Patients and\\or relatives / representatives of the parental authority in measure to understandand to follow the procedures of the study * Consent of patient and\\or parents / representatives of the parental authority * Patient member to the Social Security Exclusion Criteria: * Patient of less than 8 years * Pregnant, breast-feeding women or old enough to procreate without reliable medical contraception, * Women with a positive pregnancy test, * Transaminases \> twice the normal. * Patients with congenital ichthyosis others than LI, * Patients with a erythrodermic composent, * Patients affected by LI of the light gravity (score \< 2 for the desquamation or the roughness) on at least a side of the body, * Patients with secondary infection , * Patients with known allergy of to one of the ingredients contained in the tested product, * Patients with specific topical treatment (for example analogues of vitamin A, vitamin D similar), * Patients with topical keratolytic treatment (for example the urea, the hydroxy-acids) in 7 days before the beginning of the clinical trial * Patients and\\or relatives / representatives of the parental authority unable to understand and\\or to follow the procedures of the study, * Tea intake during the trail
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Service de dermatologie CHU de Nice
Nice, France
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Toulouse University Hospital, Dermatology Department
Toulouse, France
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