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Graphene teeth: new hope for teens with painful enamel defects?

NCT ID NCT07329244

Disease control Sponsor: Universitat Internacional de Catalunya Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new type of dental filling made with graphene, a super-strong material, for teenagers aged 10-16 who have weak enamel (a condition called MIH). The fillings are custom-made using a digital scanner and are meant to be more durable and less sensitive than standard options. Researchers will check how well they hold up over 12 months, including pain, wear, and color stability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Graphene-reinforced CAD/CAM polymer (G-CAM®) used for dental restorations
What this could lead to
If it works, this could offer a stronger, longer-lasting dental filling option for teenagers with weak enamel, reducing pain and the need for repeat treatments.
What could go wrong
This is a very small, early-stage study with only 30 participants and no comparison group. The graphene material is new, and long-term safety or durability is not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 16 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adolescents aged 10-16 years. * Permanent molars with moderate or severe MIH (EAPD criteria). * Vital and restorable teeth. * Ability to attend follow-up visits. * Informed consent from guardian + assent from the minor. Exclusion Criteria: * Fluorosis, amelogenesis imperfecta, or other enamel defects. * Severe bruxism not controlled. * Active extensive caries or irreversible pulpitis. * Systemic conditions affecting enamel or healing. * Hypersensitivity/allergy to materials/adhesives. * Use of analgesics/AINEs \<24 h before baseline VAS. * Orthodontic bands on the study molar.

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Conditions

The condition(s) this trial relates to.

dentin sensitivity Molar Hypomineralization primary failure of tooth eruption Tooth Demineralization tooth hard tissue disease tooth resorption

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Enamel mineralization disorders Indirect restoration Tooth demineralization Tooth eruption disorder Tooth sensitivity Tooth sensitivity after composite restorations

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dental Esthetic BCN

    Sarrià-Sant Gervasi, Barcelona, 08034, Spain

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