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C-Section shivering showdown: granisetron vs pethidine

NCT ID NCT06513806

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 4 trial tested two drugs—granisetron and pethidine—to treat shivering that can occur after spinal anesthesia during cesarean sections. 330 women aged 18-45 who had shivering after their C-section were given one of the two drugs. The main goal was to see how well each drug stopped the shivering, with secondary checks on pain and side effects like nausea.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
granisetron and pethidine
What this could lead to
If successful, this could show that granisetron is a safe and effective alternative to pethidine for stopping shivering after C-sections.
What could go wrong
This is a completed Phase 4 trial, so results are known. However, it only compares two drugs for a temporary side effect, not a cure or major breakthrough.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

330 people

The number who actually took part.

Started

Aug 2024

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * elective for caesarian section presence of post-spinal shivering, defined as involuntary muscle contractions occurring within operative and early recovery period after cesarean delivery. * Age 18 - 45 Exclusion Criteria * Inability to provide informed consent. * Previous allergies or sensitivities to granisetron or pethidine. * Current use of medications that may interact with granisetron or pethidine. * Presence of other conditions that may contraindicate the use of granisetron or pethidine, such as known liver or kidney disease. * Patients who are too short (\<140 cm) or too tall (\>190 cm)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia; adverse effect, spinal and epidural

Contacts and locations

Locations

  • Ain Shams University

    Cairo, Egypt

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