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Mind over menstrual pain: brain retraining could offer Drug-Free relief

NCT ID NCT07618832

Symptom relief Sponsor: Dr. Mehak Naeem Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether graded motor imagery—a brain-training program that includes recognizing body positions, imagining pain-free movements, and using mirror therapy—can reduce pain sensitivity and intensity in women with primary dysmenorrhea (painful periods with no medical cause). Researchers will compare the active program to a sham version and a wait-list group. 81 women aged 18–30 will participate in a 6-week online program led by a physiotherapist.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
graded motor imagery (a brain-training program involving laterality recognition, motor imagery, and mirror therapy)
What this could lead to
If it works, this could offer a drug-free way to ease period pain and reduce pain sensitivity for women with primary dysmenorrhea.
What could go wrong
This is a small, early-stage trial with 81 participants. The intervention is behavioral and may not work for everyone; results may not generalize to all women with period pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 81 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Female sex (aged 18-30 years) 2. Diagnosis of primary dysmenorrhea confirmed by a physician (painful menstruation for ≥6 consecutive cycles, in the absence of identifiable pelvic pathology on clinical and/or ultrasound evaluation) 3. Pain ≥4/10 NRS experienced during the last period. 4. Confirmed altered pressure pain threshold: PPT ≥2 standard deviations below published norms for age-matched healthy women, measured at baseline assessment 5. Regular menstrual cycle (21-35 days) 6. Capable of engaging in virtual video sessions and taking online tests. 7. Consent to withhold new analgesic or hormonal treatments during the study period. Exclusion Criteria: 1. Secondary dysmenorrhea (endometriosis, adenomyosis, fibroids, pelvic inflammatory disease, ovarian cysts ≥3 cm confirmed on imaging) 2. Current use of hormonal contraceptives (which alter prostaglandin levels and pain processing) 3. Pregnancy or lactation 4. Concurrent chronic pain condition (fibromyalgia, CRPS, chronic low back pain, chronic pelvic pain unrelated to menstruation) 5. Neurological or psychiatric disorder that would impair motor imagery ability (stroke, schizophrenia, active psychosis) 6. Cognitive impairment affecting informed consent capacity 7. Participation in another clinical trial within 4 weeks before enrollment 8. Previous exposure to graded motor imagery or mirror therapy 9. Regular use of NSAIDs or opioids for non-menstrual indications

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Conditions

The condition(s) this trial relates to.

primary dysmenorrhea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary dysmenorrhea (PD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Dr. Saqib Rabbani

    RECRUITING

    Lahore, Punjab Province, 54782, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.