New study tests if GP-pharmacist teamwork can help patients quit antidepressants safely
NCT ID NCT07398053
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new approach where general practitioners and pharmacists work together to help adults who have been taking antidepressants for a long time but are feeling stable. The goal is to see if this teamwork helps more people safely stop their medication without their depression coming back. The study will compare this new approach to usual care over two years in GP practices across Belgium.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- structured GP-pharmacist collaboration (behavioural intervention)
- What this could lead to
- If it works, this could provide a safe, supportive way for many people to stop long-term antidepressants without their depression returning.
- What could go wrong
- This is a relatively small trial (324 people) testing a behavioural approach, not a drug. Success depends on patient and doctor willingness, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 324 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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May 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients will be eligible for inclusion in the study if they meet all of the following criteria: * Are 18 years or older and capable of providing informed consent. * Have their Global Medical File (GMD) managed by one of the participating GPs. * Have been prescribed AD (any type) by their GP for the treatment of depression, with: * at least 6 months of continuous daily use following a first depressive episode, or * at least 2 years of continuous daily use in the context of a relapsed depression/recurrent episode * Are judged by their GP as no longer meeting the criteria for a current depressive disorder. Exclusion Criteria: Patients will be excluded from participation in the study if they meet any of the following criteria: * AD discontinuation is considered contra-indicated by the treating GP. * The patient is judged by the GP to be at high risk of relapse. This includes any of the following: * Current significant depressive symptoms, defined as a score of ≥12 on the PHQ-9 * Current significant anxiety symptoms, defined as a score of ≥10 on the Generalised Anxiety Disorder-7 (GAD-7) scale. * Current suicidal ideation, defined as a score \>0 on item 9 (suicidality) of the PHQ-9. * The patient is currently receiving only psychiatric treatment (out- or inpatient) for depression In addition to the criteria increasing the risk of relapse, the following will also be an exclusion criteria: * The patient has a current psychiatric comorbidity (e.g. bipolar disorder, psychosis, substance use) * The patient has a diagnosis of dementia or significant cognitive impairment (assessed by GP judgement) or is living in a nursing home. * The AD is prescribed for a primary indication other than depression, such as anxiety alone without comorbid depressive disorder, or chronic pain. * The patient has insufficient language proficiency in Dutch or French to participate in the study procedures (e.g. providing consent, completion of questionnaires, interviews). * use of trazodon as AD as this is mainly used for sleep problems
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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