Fluid strategy during surgery may change airway size, study finds
NCT ID NCT07477392
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 145 adults having spine surgery lasting over 2 hours. Researchers compared standard fluid therapy (based on weight and vital signs) with goal-directed therapy (using a heart monitor to guide fluids). They measured tongue and epiglottis thickness with ultrasound to see if the fluid method made a difference. The goal was to understand how fluid management affects airway swelling, not to treat a disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Goal-directed fluid therapy (intravenous fluids guided by pulse pressure variation)
- What this could lead to
- If successful, this could help doctors choose the best fluid strategy to reduce airway swelling after long surgeries.
- What could go wrong
- This is a small, completed study focused on measurements, not a treatment. Results may not change practice or apply to other surgeries.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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145 people
The number who actually took part.
- Started
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Mar 2023
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18-65 years old * ASA (American Association of Anesthesiologists) I and II * Elective spine surgery in prone position * Surgeries longer than 120 minutes Exclusion Criteria: * Chronic pulmonary disease * Renal dysfunction (glomerular filtration rate \<30 ml/kg/min) * Congestive heart failure (ejection fraction ≤35%) * Serious arrhythmias * Peripheral vascular disease * Pregnance * Patients with coagulation disorders * Patients who need more than 2 intubation attempts * Prior cervical surgery * Patients with neck extension limitation * Upper respiratory tract infection in the last 3 weeks * Patients expected to have a difficult airway (Mallampati III-IV) * Patients with a body mass index (BMI) of 35 and above * Patient's refusal
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Izmir Bozyaka Training and Research Hospital
Izmir, Bozyaka, 35100, Turkey (Türkiye)
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