Lupus drug may harm fertility – can a hormone shot save it?
NCT ID NCT05567198
First seen Apr 09, 2026 · Last updated Jun 23, 2026 · Updated 13 times
Summary
This study surveys women under 40 with lupus who are starting a chemotherapy-like drug called cyclophosphamide, which can damage ovaries and cause early menopause. Some of these women also received a hormone drug called GnRHa to protect their ovaries. Researchers will compare the two groups to see if GnRHa helps preserve ovarian function and fertility. The study uses questionnaires and medical records, not new treatments.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
gonadotropin-releasing hormone agonist (GnRHa)
What this could lead to
If this study shows GnRHa helps preserve ovarian function, it could lead to better fertility protection for women with lupus who need cyclophosphamide.
What could go wrong
This is an observational survey, not a controlled trial, so it can only suggest associations, not prove cause and effect. Results depend on accurate self-reporting and medical records.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.