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Steroid mystery: study aims to personalize dosing for kids

NCT ID NCT02252237

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 146 children taking common steroids (prednisone, prednisolone, methylprednisolone, hydrocortisone) to understand why their bodies process these drugs so differently. By analyzing blood samples and genetic factors, researchers hope to find clues that could lead to safer, more effective dosing. The study is complete and focused on gathering knowledge, not testing a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Prednisone, prednisolone, methylprednisolone, hydrocortisone (corticosteroids)
What this could lead to
If successful, this could lead to more personalized steroid dosing for children, reducing side effects and improving treatment effectiveness.
What could go wrong
This is an observational study, not a treatment trial. It may not directly change clinical practice, and results may not apply to all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

146 people

The number who actually took part.

Started

Dec 2014

Finished

Dec 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Children receiving glucocorticoids (Prednisone or Prednisolone or Methylprednisolone or hydrocortisone) are recruited in Immuno-hematological unit, dermatological unit, in pediatric nephrological unit, pediatric intensive care unit, or pediatric neurology unit

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * receiving Prednisone or Prednisolone or Methylprednisolone or hydrocortisone * recruited in Immuno-hematological unit, dermatological unit, in pediatric nephrological unit, pediatric intensive care unit, or pediatric neurology unit * parental agreement Exclusion Criteria: * parental refusal * inability to take a blood sample * inhaled corticoids intake in the 3 previous days * topical corticoids intake in the 3 previous days

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Children receiving prednisone or prednisolone or methylprednisolone or hydrocortisone

Contacts and locations

Locations

  • AP-HP Necker

    Paris, 75015, France