New drug aims to speed chemo clearance in tough brain cancers
NCT ID NCT03684980
Summary
This early-phase study is testing whether adding a drug called glucarpidase (Voraxaze) to the standard chemotherapy for central nervous system lymphoma helps the body clear the main chemotherapy drug, methotrexate, more quickly. The goal is to see if this reduces methotrexate levels in the blood faster, which could lower the risk of serious side effects like kidney damage. The study is enrolling adults with this type of lymphoma who are eligible for standard treatment.
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Contacts and locations
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Locations
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cleveland Clinic (Data Collection and Specimen Collection)
Cleveland, Ohio, 44195, United States
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Dana Farber Cancer Institute (Data Collection and Specimen Analysis)
Boston, Massachusetts, 02115, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
Conditions
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