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Weight loss jab shows promise for rare obesity syndrome

NCT ID NCT07602803

Disease control Sponsor: The Queen Elizabeth Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how safe and effective weekly weight loss injections (like Mounjaro) are for adults with Bardet-Biedl Syndrome (BBS), a rare genetic condition that often causes severe obesity. Researchers compared weight changes in 300 patients who took the medication versus those who did not. The goal was to see if these injections can help manage weight long-term in people with BBS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

300 people

The number who actually took part.

Started

Jan 2023

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All the patients with a genetic diagnosis of BBS living in the UK under the UK National BBS Centres (Birmingham and London).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All the adult patients with a genetic diagnosis of BBS under the national BBS centres (London and Birmingham in the UK). Exclusion Criteria: * Adult patients with a genetic diagnosis of BBS under the national BBS centres (London and Birmingham in the UK) who lost follow ups or significant missing data, or BMI\<30 in patients without GLP1 agonists.

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Conditions

The condition(s) this trial relates to.

Bardet-Biedl syndrome Obesity Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Barded-biedl syndrome Bardet Biedl syndrome

Contacts and locations

Locations

  • Queen Elizabeth Hospital Birmingham

    Birmingham, West Midlands, B15 2GW, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.