Could a single surgery replace daily eye drops for glaucoma?
NCT ID NCT07700498
First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time
Summary
This trial tests whether combining cataract surgery with a procedure called gonioscopy-assisted trabeculotomy (GAT) can reduce the need for long-term glaucoma eye drops in adults with both primary open-angle glaucoma and cataracts. Participants will either receive the combined surgery or cataract surgery followed by standard eye drops. The study tracks eye pressure, eye surface health, and quality of life over 24 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- phacoemulsification combined with gonioscopy-assisted trabeculotomy
- What this could lead to
- If successful, this approach could reduce or eliminate the need for daily glaucoma eye drops, improving quality of life and eye surface health.
- What could go wrong
- This is a relatively small trial, and the surgery carries risks like infection or inflammation. It may not work for everyone, and long-term benefits are still uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 106 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Provides written informed consent voluntarily. * Age 40 to 85 years. * Male or female. * Treatment-naive for glaucoma, with no prior IOP-lowering medication, glaucoma laser procedure, or glaucoma surgery. * Lens opacity causing decreased visual quality and clinically significant cataract. * Diagnosis of POAG combined with cataract by the treating ophthalmologist. * Best-corrected visual acuity of 0.1 or better on the Snellen chart, corresponding to LogMAR 1.0 or less. * Ability and willingness to complete scheduled follow-up visits and study examinations. Exclusion Criteria: * Secondary glaucoma, including uveitic, pseudoexfoliative, pigmentary, steroid-induced, neovascular, traumatic, or other secondary glaucoma. * Angle-closure glaucoma or narrow angle inconsistent with POAG. * POAG without visually significant cataract. * Previous anti-glaucoma medication use, glaucoma surgery, or glaucoma laser treatment. * Advanced visual field loss, defined as visual field mean deviation worse than -12 dB. * Severe ocular comorbidity or inability to perform reliable visual acuity testing. * Known contraindication to required study medications. * Average RNFL thickness or GCIPL thickness less than 54 micrometers. * Axial length greater than 26 mm. * Monocular status or functional vision in only one eye. * Inability to complete reliable visual field or OCT testing. * Systemic disease that may affect ocular status or study assessment, including diabetes mellitus, uncontrolled hypertension, malignancy, renal disease, autoimmune disease, neurological disease, liver disease, cardiovascular disease, or systemic inflammatory disease. * Visual impairment mainly attributable to disease other than POAG or cataract. * Pregnancy, lactation, or planned pregnancy during the study period.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
5 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Nanfang Hospital, Southern Medical University
RECRUITINGGuangzhou, China
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People's Hospital of Ningxia Hui Autonomous Region
NOT_YET_RECRUITINGNingxia, Ningxia, China
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The Affiliated Hospital of Southwest Medical University
NOT_YET_RECRUITINGLuzhou, China
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The First Affiliated Hospital of Zhengzhou University
NOT_YET_RECRUITINGZhengzhou, China
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Zhuhai Hospital of Guangdong Provincial Hospital of Chinese Medicine
NOT_YET_RECRUITINGZhuhai, China