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Scientists hunt for DNA signs that reveal dangerous staph infections

NCT ID NCT03374371

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at the DNA of Staphylococcus epidermidis bacteria from 320 patients to find genetic markers that separate harmless strains from those that cause serious infections. The goal is to help doctors decide when antibiotics are truly needed. No new treatment was tested; instead, researchers analyzed existing samples to improve diagnosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

320 people

The number who actually took part.

Started

Mar 2018

Finished

Dec 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Population 1 (bacteraemia related to intravascular devices) : patients hospitalized for at least 48 hours including new-borns Population 2 (infections of materials) : patients carrying medical devices implanted following an act of surgery (orthopedic, cardiac or neurosurgery)

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: CASE Inclusion Criteria: Population 1: nosocomial bacteraemia associated with intravascular devices 1. Hospitalized patient with intravascular device (peripheral or central, venous or arterial, short or long duration) for at least 48 hours before the development of bacteraemia 2. Presenting a definite infection with S. epidermidis according to the categorization criteria, Sub-Population 1A: 3a) Aged less than 28 days (New-born) Sub-population 1B: 3b) Aged 28 days or more Population 2: nosocomial infections of implanted material 1. An operated patient carrying implanted equipment following orthopaedic surgery, following cardiac surgery or following neurosurgery, 2. Presenting a definite infection with S. epidermidis according to the categorization criteria occurring in the year following surgery CONTROL Inclusion Criteria: Population 1: carrier of intravascular devices 1. Hospitalized patient with intravascular device (peripheral or central, venous or arterial, short or long duration) for at least 48 hours before positive blood culture with S. epidermidis 2. Certain contamination with S. epidermidis according to the categorization criteria, Sub-Population 1A: 3a) Aged less than 28 days (Newborn) Sub-population 1B: 3b) Aged 28 days or more Population 2: carrier of implanted material 1. An operated patient carrying implanted equipment following orthopedic surgery, following cardiac surgery or following neurosurgery, 2. Presenting a certain contamination to S. epidermidis according to the categorization criteria occurring in the year following surgery Exclusion Criteria: CASE Exclusion Criteria Population 1: nosocomial bacteremia associated with intravascular devices 1. Opposition of the patient or the holders of parental authority (minor patients) 2. Patient with polymicrobial infection 3. Patient with a colonized catheter (positive catheter end culture \<103UFC / mL) with no clinical signs of local or general infection and with sterile peripheral blood cultures 4. Patient with local catheter infection (positive catheter end culture\> 103UFC / mL) with local inflammatory signs only and with sterile peripheral blood cultures Population 2: nosocomial infections of implanted material 1. Opposition of the patient or the holders of parental authority (minor patients) 2. Patient with an infection of material concomitant with a catheter-related infection CONTROL Exclusion Criteria Populations 1 and 2: Opposition of the patient or the holders of parental authority (minor patients)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hôpital Necker Enfants Malades

    Paris, Île-de-France Region, 75015, France