Scientists hunt for DNA signs that reveal dangerous staph infections
NCT ID NCT03374371
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at the DNA of Staphylococcus epidermidis bacteria from 320 patients to find genetic markers that separate harmless strains from those that cause serious infections. The goal is to help doctors decide when antibiotics are truly needed. No new treatment was tested; instead, researchers analyzed existing samples to improve diagnosis.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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320 people
The number who actually took part.
- Started
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Mar 2018
- Finished
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Dec 2020
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Population 1 (bacteraemia related to intravascular devices) : patients hospitalized for at least 48 hours including new-borns Population 2 (infections of materials) : patients carrying medical devices implanted following an act of surgery (orthopedic, cardiac or neurosurgery)
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: CASE Inclusion Criteria: Population 1: nosocomial bacteraemia associated with intravascular devices 1. Hospitalized patient with intravascular device (peripheral or central, venous or arterial, short or long duration) for at least 48 hours before the development of bacteraemia 2. Presenting a definite infection with S. epidermidis according to the categorization criteria, Sub-Population 1A: 3a) Aged less than 28 days (New-born) Sub-population 1B: 3b) Aged 28 days or more Population 2: nosocomial infections of implanted material 1. An operated patient carrying implanted equipment following orthopaedic surgery, following cardiac surgery or following neurosurgery, 2. Presenting a definite infection with S. epidermidis according to the categorization criteria occurring in the year following surgery CONTROL Inclusion Criteria: Population 1: carrier of intravascular devices 1. Hospitalized patient with intravascular device (peripheral or central, venous or arterial, short or long duration) for at least 48 hours before positive blood culture with S. epidermidis 2. Certain contamination with S. epidermidis according to the categorization criteria, Sub-Population 1A: 3a) Aged less than 28 days (Newborn) Sub-population 1B: 3b) Aged 28 days or more Population 2: carrier of implanted material 1. An operated patient carrying implanted equipment following orthopedic surgery, following cardiac surgery or following neurosurgery, 2. Presenting a certain contamination to S. epidermidis according to the categorization criteria occurring in the year following surgery Exclusion Criteria: CASE Exclusion Criteria Population 1: nosocomial bacteremia associated with intravascular devices 1. Opposition of the patient or the holders of parental authority (minor patients) 2. Patient with polymicrobial infection 3. Patient with a colonized catheter (positive catheter end culture \<103UFC / mL) with no clinical signs of local or general infection and with sterile peripheral blood cultures 4. Patient with local catheter infection (positive catheter end culture\> 103UFC / mL) with local inflammatory signs only and with sterile peripheral blood cultures Population 2: nosocomial infections of implanted material 1. Opposition of the patient or the holders of parental authority (minor patients) 2. Patient with an infection of material concomitant with a catheter-related infection CONTROL Exclusion Criteria Populations 1 and 2: Opposition of the patient or the holders of parental authority (minor patients)
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Necker Enfants Malades
Paris, Île-de-France Region, 75015, France