Lung cancer in Never-Smokers: genes may hold the key
NCT ID NCT00597636
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aims to understand why some people who have never smoked develop lung cancer. Researchers are comparing the genes of never-smokers with lung cancer to those without the disease. The goal is to find genetic differences that might increase risk. This is a research study only and will not provide direct treatment or results to participants.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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238 people
The number who actually took part.
- Start date
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Jun 2005
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
MSKCC clinics
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Cases will be eligible for inclusion if: * They have been diagnosed with a lung cancer or have had previous surgical treatment for their lung cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and * They have had no prior chemotherapy or radiation treatment within the last year (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected) * They speak and read English * They understand and agree to sign informed consent, and * They agree to give us a blood sample, and * They agree to complete the study questionnaire, and * They agree to have their pathology information reviewed by study personnel. * Controls will be eligible for inclusion if: * They have not been diagnosed with any type of cancer, exclusive of nonmelanoma skin cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and * They speak and read English * They understand and agree to sign informed consent, and * They agree to give us a blood sample, and * They agree to complete the study questionnaire. Exclusion Criteria: * Subjects who do not meet the inclusion criteria for either the case or control groups will not be eligible for this study. * All individuals who otherwise meet the eligibility requirements above, but who have had chemotherapy or radiation therapy within 1 year of evaluation will be excluded (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected).
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Memorial Sloan-Kettering Cancer Center
New York, New York, 10065, United States
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Other studies related to the condition(s) this trial covers.
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