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Gene hunt: could DNA explain tough behavior in kids?

NCT ID NCT07322055

Knowledge-focused Sponsor: IRCCS Fondazione Stella Maris Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how genes might be linked to behavior in 200 children aged 7-16 with disruptive behavior disorders like Conduct Disorder or Oppositional Defiant Disorder. Some of these children also have callous-unemotional traits, such as lack of guilt or shallow emotions. Researchers will compare genetic profiles with clinical data to better understand why some children develop more severe symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help identify genetic factors that influence behavior, potentially leading to better risk assessment and personalized support for children with disruptive behavior disorders.
What could go wrong
This is an observational study, not a treatment trial. It only looks for correlations, so it cannot prove cause and effect. The findings may not apply to other ethnic groups or ages.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of children and adolescents aged 7-16 years diagnosed with Conduct Disorder or Oppositional Defiant Disorder and treated at a specialized outpatient clinic for childhood behavioral disorders.

Ages

7 to 16 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Primary diagnosis of Conduct Disorder or Oppositional Defiant Disorder, obtained using the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime version (K-SADS-PL); * Age 7-16 years; * Intelligence Quotient \> 85; * Italian nationality and Caucasian ethnicity (excluding Sardinians for reasons of ethnic uniformity); * No relatives already enrolled in the study. Exclusion Criteria: * Lack of signed Informed Consent; * Diagnosis of Pervasive Developmental Disorder according to K-SADS-PL.

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Conditions

The condition(s) this trial relates to.

conduct disorder oppositional defiant disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Callous-unemotional traits Conduct disorder Oppositional defiant disorder

Contacts and locations

Locations

  • IRCCS Fondazione Stella Maris

    Pisa, Pisa, 56128, Italy

  • Università di Pisa

    Pisa, Pisa, 56126, Italy

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