Brain injection trial aims to slow devastating dementia
NCT ID NCT04747431
Summary
This early-stage study is testing a one-time gene therapy injection for adults with specific genetic forms of frontotemporal dementia (FTD). The treatment, called PBFT02, aims to deliver a working copy of a missing or faulty gene directly to the brain to potentially slow disease progression. Researchers will primarily monitor safety and look for early signs of biological effect in about 30 participants over five years.
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Contacts and locations
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Study contacts
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Centro Hospitalar e Universitário de Coimbra
RECRUITINGCoimbra, Portugal
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Eastern Health-Box Hill Hospital
RECRUITINGMelbourne, Victoria, 3128, Australia
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Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP)
RECRUITINGSão Paulo, Brazil
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Hospital das Clinicas da Universidade Federal de Minas Gerais (UFMG)
RECRUITINGMinas Gerais, Brazil
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Michigan Alzheimer's Disease Center
RECRUITINGAnn Arbor, Michigan, 48105, United States
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Montreal Neurological Institute-Hospital
RECRUITINGMontreal, Quebec, H3A 2B4, Canada
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Texas at Houston
RECRUITINGHouston, Texas, 77030, United States
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University of Toronto, Toronto Western Hospital
RECRUITINGToronto, Ontario, M5T 2S8, Canada
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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Conditions
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