Gene therapy trial aims to cure deafness in children

NCT ID NCT05788536

Recruiting now ⭐️ CURE ⭐️ Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This trial is testing a one-time gene therapy called DB-OTO in children and infants born deaf due to a specific genetic mutation (OTOF). The goal is to see if a single injection into the inner ear is safe and can restore hearing. Researchers will measure if children can hear sounds at normal conversation levels after treatment.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Addenbrooke's Hospital, Cambridge University Hospitals NHS FT
RECRUITING

Cambridge, CB2 0QQ, United Kingdom

Contact Email: •••••@•••••
Boston Children's Hospital - Main
RECRUITING

Boston, Massachusetts, 02115, United States

Contact Email: •••••@•••••
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States

Contact Email: •••••@•••••
Clinica Universidad de Navarra- Pamplona
RECRUITING

Pamplona, Navarre, 31008, Spain

Contact Email: •••••@•••••
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Great Ormond Street Hospital For Children NHS Foundation Trust
RECRUITING

London, WC1N 3JH, United Kingdom

Contact Email: •••••@•••••
Hospital Universitario Materno Infantil en las Palmas de Gran Canaria
WITHDRAWN

Las Palmas de Gran Canaria, 35016, Spain
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

Contact Email: •••••@•••••
Nemours Children s Clinic
RECRUITING

Jacksonville, Florida, 32207, United States

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Nemours Childrens Hospital
RECRUITING

Orlando, Florida, 32827, United States

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Rady Children's Hospital
RECRUITING

San Diego, California, 92123, United States

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Ramon y Cajal University Hospital
RECRUITING

Madrid, 28034, Spain

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Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States

Contact Email: •••••@•••••
University Hospital Tubingen
RECRUITING

Tübingen, 72076, Germany

Contact Email: •••••@•••••
University of California Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90024, United States

Contact Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

CONGENITAL HEARING LOSS SECONDARY TO BIALLELIC MUTATIONS OF THE OTOFERLIN GENE (OTOF)