Gene therapy trial aims to cure deafness in children

NCT ID NCT05788536

RECRUITING ⭐️ CURE ⭐️ Sponsor: Regeneron Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This trial is testing a one-time gene therapy called DB-OTO for children born deaf due to a specific genetic mutation in the OTOF gene. The goal is to restore hearing by delivering a functional copy of the gene directly into the inner ear. Researchers will assess the safety of the treatment and measure how well it improves hearing sensitivity and speech perception.

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Addenbrooke's Hospital, Cambridge University Hospitals NHS FT
RECRUITING

Cambridge, CB2 0QQ, United Kingdom

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Boston Children's Hospital - Main
RECRUITING

Boston, Massachusetts, 02115, United States

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Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States

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Clinica Universidad de Navarra- Pamplona
RECRUITING

Pamplona, Navarre, 31008, Spain

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Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States

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Great Ormond Street Hospital For Children NHS Foundation Trust
RECRUITING

London, WC1N 3JH, United Kingdom

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Hospital Universitario Materno Infantil en las Palmas de Gran Canaria
WITHDRAWN

Las Palmas de Gran Canaria, 35016, Spain
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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Nemours Children s Clinic
RECRUITING

Jacksonville, Florida, 32207, United States

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Nemours Childrens Hospital
RECRUITING

Orlando, Florida, 32827, United States

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Rady Children's Hospital
RECRUITING

San Diego, California, 92123, United States

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Ramon y Cajal University Hospital
RECRUITING

Madrid, 28034, Spain

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Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States

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University Hospital Tubingen
RECRUITING

Tübingen, 72076, Germany

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University of California Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90024, United States

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