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Experimental gene therapy aims to slow vision loss from dry AMD

NCT ID NCT05811351

Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a gene therapy called JNJ-81201887 in 305 people with geographic atrophy, a late stage of dry age-related macular degeneration that causes blind spots. The treatment is injected into the eye and aims to slow the growth of damaged areas. Researchers measured changes in lesion size and vision over 18 months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

305 people

The number who actually took part.

Started

Mar 2023

Finished

Feb 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have non-subfoveal (defined as not involving the center point of the fovea) geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with an area that can be measured and measures 2.5 millimeter square (mm\^2) to 17.5 mm\^2 (1- and 7- disc areas respectively), determined by the central reading center (CRC) from screening images of fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) * If GA is multifocal, at least one focal lesion must be greater than or equal to (\>=) 1.25 mm\^2 (0.5- disc area), as assessed by the CRC * GA can be photographed in its entirety by FAF, using a 30- degree image centered on the fovea, as assessed by the CRC * Fellow eye must be present with a best corrected distance visual acuity (BCVA) of counting fingers or better * Man or woman (according to their reproductive organs and functions assigned by chromosomal complement) Exclusion Criteria: * History of transpupillary thermotherapy, photodynamic therapy or external-beam radiation therapy in the region of study eye * Any prior thermal laser in the macular region, regardless of indication * History of retinal detachment (with or without repair) * Active, infectious conjunctivitis, keratitis, scleritis, or endophthalmitis * Any sign of diabetic retinopathy or central serous chorioretinopathy

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration dry age related macular degeneration Geographic Atrophy macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Geographic atrophy

Contacts and locations

Locations

  • AXON Clinical s.r.o.

    Prague, 15000, Czechia

  • Aalborg University Hospital

    Aalborg, 9000, Denmark

  • Adelaide Eye and Retina Centre

    Adelaide, 5000, Australia

  • Alberta Retina Consultants

    Edmonton, Alberta, T5H 0X5, Canada

  • Amsterdam University Medical Centers Location Academic Medical Center

    Amsterdam, 1105 AZ, Netherlands

  • Ankara Bilkent Sehir Hastanesi

    Ankara, 06800, Turkey (Türkiye)

  • Arcispedale S. Anna Ferrara

    Ferrara, 44124, Italy

  • Asheville Eye Associates - Western Carolina Retinal Associates

    Asheville, North Carolina, 28803, United States

  • Associated Retinal Consultants P.C.

    Royal Oak, Michigan, 48073, United States

  • Augenzentrum am St Franziskus Hospital Munster

    Münster, 48145, Germany

  • Austin Clinical Research

    Austin, Texas, 78750, United States

  • Azienda Ospedaliera Univ.- Università Degli studi della Campania - Luigi Vanvitelli

    Naples, 80138, Italy

  • Baskent University Ankara Hospital

    Ankara, 06490, Turkey (Türkiye)

  • Bay Area Retina Associates

    Walnut Creek, California, 94598, United States

  • Bristol Eye Hospital

    Bristol, BS1 2LX, United Kingdom

  • Calgary Retina Consultants

    Calgary, Alberta, T2H 0C8, Canada

  • California Eye Medical Specialists

    Pasadena, California, 91107, United States

  • California Retina Consultants

    Oxnard, California, 93036, United States

  • Cascade Medical Research Institute, LLC

    Springfield, Oregon, 97477, United States

  • Casey Eye Institute

    Portland, Oregon, 97239, United States

  • Central Middlesex Hospital

    London, NW10 7NS, United Kingdom

  • Centre Hospitalier Universitaire de Liege Domaine Universitaire du Sart Tilman

    Liège, 4000, Belgium

  • Centre for Eye Research Australia

    East Melbourne, 3002, Australia

  • Centro Medico Teknon S.L.

    Barcelona, 08022, Spain

  • Centro de Oftalmologia Barraquer

    Barcelona, 08021, Spain

  • Charite Universitaetsmedizin Berlin

    Berlin, 12203, Germany

  • Charles Retina Institute

    Germantown, Tennessee, 38138, United States

  • Charleston Neuroscience Institute, LLC

    Beaufort, South Carolina, 29902, United States

  • Cincinnati Eye Institute

    Cincinnati, Ohio, 45242, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Clinica Baviera Madrid Castellana

    Madrid, 28046, Spain

  • Clinica Oftalvist Valencia

    Burjassot, 46100, Spain

  • Clinica Univ. de Navarra

    Pamplona, 31008, Spain

  • Colorado Retina - Lakewood Clinic

    Lakewood, Colorado, 80228, United States

  • Cumberland Valley Retina Consultants

    Hagerstown, Maryland, 21740, United States

  • Dokuz Eylul University Hospital

    Izmir, 35330, Turkey (Türkiye)

  • Duke University

    Durham, North Carolina, 27705-4699, United States

  • East Florida Eye Institute

    Stuart, Florida, 34994, United States

  • Erie Retina Research

    Erie, Pennsylvania, 16505, United States

  • Espaco Medico de Coimbra

    Coimbra, 3030-163, Portugal

  • Eszak Pesti Centrumkorhaz Honvedkorhaz

    Budapest, 1062, Hungary

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, 100 34, Czechia

  • Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano

    Milan, 20122, Italy

  • Fort Lauderdale Eye Institute

    Plantation, Florida, 33324, United States

  • Foundation for Vision Research

    Grand Rapids, Michigan, 49546, United States

  • Ganglion Orvosi Központ

    Pécs, 7621, Hungary

  • Georgia Retina

    Marietta, Georgia, 30060, United States

  • Graystone Eye

    Hickory, North Carolina, 28602, United States

  • Hacettepe University Hospital

    Ankara, 06230, Turkey (Türkiye)

  • Het Oogziekenhuis Rotterdam

    Rotterdam, 3011, Netherlands

  • Hosp Univ Fund Jimenez Diaz

    Madrid, 28040, Spain

  • Hosp. Clinico Univ. Lozano Blesa

    Zaragoza, 50009, Spain

  • Hosp. Dos de Maig

    Barcelona, 08025, Spain

  • Hosp. La Arruzafa

    Córdoba, 14012, Spain

  • Hosp. Prov. Do Conxo

    Santiago de Compostela, 15706, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. Donostia

    Donostia / San Sebastian, 20014, Spain

  • Hosp. Univ. Miguel Servet

    Zaragoza, 50009, Spain

  • Hosp. Univ. Pta. de Hierro Majadahonda

    Majadahonda, 28222, Spain

  • Hosp. Virgen Del Rocio

    Seville, 41013, Spain

  • Houston Eye Associates

    Houston, Texas, 77025, United States

  • Idc Salud Hosp. Gral. de Catalunya

    Sant Cugat del Vallès, 08195, Spain

  • Inselspital Universitatsspital Bern

    Bern, 3010, Switzerland

  • Inst. Cat. de Retina

    Barcelona, 08022, Spain

  • Inst. de Microcirugia Ocular

    Barcelona, 08035, Spain

  • Institut De L'oeil Des Laurentides

    Boisbriand, Quebec, J7H 0E8, Canada

  • Jules Stein Eye Institute UCLA

    Los Angeles, California, 90095, United States

  • Klinikum Gottingen der Georg August Universitat

    Göttingen, 37075, Germany

  • Klinikum Ludwigshafen

    Ludwigshafen am Rhein, 67063, Germany

  • Konya Selcuk University Medical Faculty

    Konya, 42250, Turkey (Türkiye)

  • Long Island Vitreo Retinal Consultants

    Great Neck, New York, 11021, United States

  • Maine Eye Center

    Portland, Maine, 04101, United States

  • Manchester Royal Eye Hospital

    Manchester, M13 9WL, United Kingdom

  • Marietta Eye Clinic

    Marietta, Georgia, 30060, United States

  • MedEye Associates

    Miami, Florida, 33143, United States

  • Medizinische Hochschule Hannover

    Hanover, 30625, Germany

  • Midwest Eye Institute

    Carmel, Indiana, 46032, United States

  • Moorfields Eye Hospital

    London, EC1V 2PD, United Kingdom

  • NC Retina Associates

    Wake Forest, North Carolina, 27587, United States

  • National Opthalmic Research Institute

    Fort Myers, Florida, 33912, United States

  • OFTEX Ltd. - EYE CENTER

    Pardubice, 530 02, Czechia

  • Oculomedica

    Bydgoszcz, 85 157, Poland

  • Oftalmika

    Bydgoszcz, 85 631, Poland

  • Ophthalmic Consultants of Boston

    Boston, Massachusetts, 02114, United States

  • Opthalmic Consultants of the Capital Region

    Troy, New York, 12180, United States

  • Ospedale San Raffaele

    Milan, 20132, Italy

  • Oxford Eye Hospital

    Oxford, OX3 9DU, United Kingdom

  • Panhandle Eye Group LLP-Southwest Retina Specialists

    Amarillo, Texas, 79106, United States

  • Piedmont Eye Center

    Lynchburg, Virginia, 24502, United States

  • Policlinico Universitario Agostino Gemelli

    Roma, 00168, Italy

  • Radboudumc

    Nijmegen, 6525 GA, Netherlands

  • Retina Associates

    Elmhurst, Illinois, 60126, United States

  • Retina Associates Of South Texas P A

    San Antonio, Texas, 78240, United States

  • Retina Associates Of Southern California

    Huntington Beach, California, 92647, United States

  • Retina Associates Southwest PC

    Tucson, Arizona, 85704, United States

  • Retina Associates of Utah P C

    Salt Lake City, Utah, 84107, United States

  • Retina Consultants PLLC

    Slingerlands, New York, 12159, United States

  • Retina Consultants San Diego

    Poway, California, 92064, United States

  • Retina Consultants of Minnesota

    Saint Louis Park, Minnesota, 55416, United States

  • Retina Consultants of Orange County

    Fullerton, California, 92835, United States

  • Retina Consultants of Southern California

    Redlands, California, 92374, United States

  • Retina Consultants of Texas

    San Antonio, Texas, 78240, United States

  • Retina Consultants of Texas

    The Woodlands, Texas, 77384, United States

  • Retina Consultants of Texas 2

    Bellaire, Texas, 77401, United States

  • Retina Foundation of the Southwest

    Dallas, Texas, 75231, United States

  • Retina Group of Florida

    Fort Lauderdale, Florida, 33308, United States

  • Retina Research Institute of Texas

    Abilene, Texas, 79606, United States

  • Retina Specialists

    Baltimore, Maryland, 21204, United States

  • Retina Specialty Institute

    Pensacola, Florida, 32503, United States

  • Retina Vitreous Associates of Florida

    St. Petersburg, Florida, 33711, United States

  • Retina and Vitreous of Texas, PLLC

    Bellaire, Texas, 77401, United States

  • Retina-Vitreous Surgeons of Central New York

    Liverpool, New York, 13088, United States

  • Retinal Research Institute

    Phoenix, Arizona, 85053, United States

  • Rocky Mountain Retina Consultants

    Salt Lake City, Utah, 84107, United States

  • Royal Victoria Infirmary

    Newcastle upon Tyne, NE1 4LP, United Kingdom

  • S:t Eriks Ogonsjukhus

    Stockholm, 171 64, Sweden

  • Sacco Hospital

    Milan, 20157, Italy

  • San Antonio Eye Center

    San Antonio, Texas, 78215, United States

  • Shiley Eye Institute Jacobs Retina Center

    La Jolla, California, 92093 0946, United States

  • Sierra Eye Associates

    Reno, Nevada, 89502, United States

  • Southampton University Hospital

    Southampton, SO16 6YD, United Kingdom

  • Spokane Eye Clinical Research

    Spokane, Washington, 99204, United States

  • Stanford Health Care

    Palo Alto, California, 94303, United States

  • Strategic Clinical Research Group

    Willow Park, Texas, 76087, United States

  • Strathfield Retina Clinic

    Strathfield, 2135, Australia

  • Sydney Retina Clinic and Day Surgery

    Sydney, 2000, Australia

  • Sydney West Retina

    Westmead, 2145, Australia

  • Texas Retina Associates

    Dallas, Texas, 75231, United States

  • Texas Retina Associates 1

    Fort Worth, Texas, 76104, United States

  • The Ottawa Hospital Research Institute

    Ottawa, Ontario, K1H 8L6, Canada

  • The Retina Care Center

    Baltimore, Maryland, 21209, United States

  • The Retina Centre of Ottawa

    Ottawa, Ontario, K2B 7E9, Canada

  • The Retina Clinic London

    London, W1G 9AX, United Kingdom

  • The Retina Group of Washington

    Chevy Chase, Maryland, 20815, United States

  • The Retina Institute

    St Louis, Missouri, 63144, United States

  • The Retina Partners

    Los Angeles, California, 91436, United States

  • UT Southwestern

    Dallas, Texas, 75390, United States

  • UZ Gent

    Ghent, 9000, Belgium

  • UZ Leuven Gasthuisberg

    Leuven, 3000, Belgium

  • Uls Coimbra - Hosp. Univ. Coimbra

    Coimbra, 3000 075, Portugal

  • Uls Sao Joao - Hosp. Sao Joao

    Porto, 4200 319, Portugal

  • Universitaets-Augenklinik Bonn

    Bonn, 53127, Germany

  • Universitaetsklinikum Leipzig

    Leipzig, 04103, Germany

  • Universitaetsklinikum Muenster

    Münster, 48149, Germany

  • Universitaetsklinikum Tuebingen

    Tübingen, 72076, Germany

  • Universitatsklinikum Gießen - Klinik und Poliklinik fur Augenheilkunde

    Giessen, 35392, Germany

  • Universitatsklinikum Schleswig Holstein Kiel

    Kiel, 24105, Germany

  • University Hospital Of Copenhagen, Glostrup Hospital

    Glostrup Municipality, 2600, Denmark

  • University Of Illinois

    Chicago, Illinois, 60612, United States

  • University Retina

    Lemont, Illinois, 60439, United States

  • University of Utah

    Salt Lake City, Utah, 84132, United States

  • Uno Med

    Tarnów, 33 100, Poland

  • Verum Research LLC

    Eugene, Oregon, 97401, United States

  • Vitreo Retinal Associates-Worcester

    Worcester, Massachusetts, 01605, United States

  • VitreoRetinal Associates, PA

    Gainesville, Florida, 32607, United States

  • Vitreous Retina Macula Consultants of New York

    New York, New York, 10022, United States

  • Wagner Kapoor Research institute

    Norfolk, Virginia, 23502, United States

  • Warszawski Szpital Okulistyczny

    Warsaw, 01 258, Poland

  • Wills Eye/Mid Atlantic Retina

    Cherry Hill, New Jersey, 08034, United States

  • Zala Megyei Szent Rafael Korhaz

    Zalaegerszeg, 8900, Hungary

  • Zealand University Hospital

    Roskilde, 4000, Denmark

  • Ziekenhuis Oost-Limburg

    Genk, 3600, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.