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Engineered immune cells take on Hard-to-Treat tumors in early trial

NCT ID NCT07297667

First seen Jan 11, 2026 · Last updated Apr 24, 2026 · Updated 16 times

Summary

This early-phase study tests a new treatment called GCAR1, which uses a patient's own immune cells (T-cells) that are modified in a lab to recognize and attack cancer cells that have a specific marker (GPNMB). The study enrolls up to 30 people in Canada with advanced sarcoma, kidney cancer, or triple-negative breast cancer that has not responded to other treatments. The main goals are to find a safe dose and see if the therapy can shrink tumors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Arthur J.E. Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

    Contact Phone: •••-•••-••••

  • Ottawa Hospital Research Institute

    Ottawa, Ontario, K1H 8L6, Canada

    Contact Phone: •••-•••-••••

  • University Health Network Princess Margaret Hospital

    Toronto, Ontario, M5G 2M9, Canada

    Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.