Vitamin c shown to briefly change stomach acidity in small study
NCT ID NCT04199624
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Phase 1 study tested whether vitamin C (ascorbic acid) tablets can temporarily reduce stomach pH (increase acidity) in 11 healthy young men whose stomach acid was lowered by the drug omeprazole. Participants took vitamin C once and had their stomach pH monitored for five hours. The study also looked at how stomach pH changes might relate to gut bacteria and metabolites.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Vitamin C (ascorbic acid)
- What this could lead to
- If successful, this could point toward a simple way to temporarily adjust stomach acidity for certain medical situations.
- What could go wrong
- This is a very small, early-phase study in healthy young men only, so results may not apply to patients or real-world conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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11 people
The number who actually took part.
- Started
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Oct 2021
- Finished
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Jun 2023
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 30 years
- Sex
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Male participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy, young males age 18-30 years with no prior history of gastrointestinal disease or symptoms. Exclusion Criteria: * Hypochlorhydria (baseline use antacids, antisecretory medications, or surface agents including proton-pump inhibitors, H2 blockers, or sucralfate). * Current or previous history of gastrointestinal disease including gastroesophageal reflux disease, Barrett's esophagus, peptic ulcer disease, dyspepsia, gastroparesis, bacterial overgrowth, microscopic colitis, gastric intestinal metaplasia or metaplastic atrophic gastritis, gastric neuroendocrine tumors, helicobacter pylori infection, inflammatory bowel disease (Crohn's disease or ulcerative colitis), celiac disease, visceral cancer, chronic infectious disease, immunodeficiency, uncontrolled thyroid disease, history of liver disease). * History of gastric bypass or other abdominal surgeries excluding cholecystectomy or appendectomy \> 6 months prior to study initiation. * Radiation therapy to the abdomen. * Pregnant females. * Ingestion of any prescription, over-the-counter, or herbal medications which may affect study interpretation. * Currently a smoker * Antibiotic use within the last 3 months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States