Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can gabapentin ease acute sciatica better than a sugar pill?

NCT ID NCT04865042

Symptom relief Sponsor: Lille Catholic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether gabapentin, a nerve pain medication, provides better short-term pain relief than a placebo for people hospitalized with acute sciatica caused by a herniated disc. 144 adults received either gabapentin or placebo on top of their usual pain treatment for three days. Researchers measured pain changes and side effects to see if gabapentin offers an advantage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Gabapentin
What this could lead to
If it works, this could confirm that adding gabapentin to standard pain relief helps people with acute sciatica feel better faster during a short hospital stay.
What could go wrong
This is a small, short-term study (72 hours) with only 144 participants. Gabapentin may not outperform placebo, and side effects like dizziness or drowsiness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

144 people

The number who actually took part.

Started

Feb 2022

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years, * Radiculalgia or lumboradiculalgia less than 3 months (pain of a lower limb systematized to a radicular territory, possibly associated with lumbar pain), * Inpatient management for a minimum of 72 hours after inclusion, * Initial radiculalgia VAS ≥ 4 (moderate to severe pain), * Concordant disc herniation between clinical symptomatology and imaging (CT or MRI) less than 3 months, * Written consent signed by the patient, * Affiliation to a social security system * For women of childbearing age, use of effective contraception Exclusion Criteria: * Motor neurological deficit (≤ 3/5) or cauda equina syndrome (emergency surgical indications), * Chronic neuropathic pain in the lower limb affected by radiculalgia, * Lumbar infiltration performed within 72 hours prior to inclusion or unable to be performed after 72 hours, * Patient already on Gabapentin or Pregabalin, or having taken these treatments in the 7 days prior to inclusion * Contraindication to Gabapentin (Hypersensitivity to the active substance or to any of the excipients: corn starch, talc, yellow iron oxide, titanium dioxide, sodium lauryl sulfate, gelatin, shellac, propylene glycol, black iron oxide and potassium hydroxide) * Creatinine clearance \< 30ml/min, * Hemodialysis patient, * Body weight \< 50kgs, * Transplant patient * Patient under guardianship or curatorship * Pregnant or breastfeeding woman

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Radiculopathy of lumbosacral spine due to disc disorder are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Intervertebral Disc Displacement radiculopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Radiculopathy of lumbosacral spine due to disc disorder

Contacts and locations

Locations

  • CH Arras-rheumatology

    Arras, France

  • CH Béthune-rheumatology

    Béthune, France

  • CH Dunkerque-rheumatology

    Dunkirk, France

  • CHU Caen-rheumatology

    Caen, France

  • CHU Rouen-rheumatology

    Rouen, France