Can a single injection tame high triglycerides?
NCT ID NCT07766759
First seen Aug 14, 2026 · Last updated Aug 14, 2026
Summary
This early-stage trial tests a single injection of an experimental drug called FXR0906 in healthy adults with slightly elevated triglycerides, a type of fat in the blood linked to heart risk. The study aims to see if the drug is safe, how the body processes it, and whether it lowers triglyceride levels. Half of the participants will receive the drug and half a placebo, with neither they nor the researchers knowing who got which.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- FXR0906 injection
- What this could lead to
- If successful, this could lead to a new once-daily injection to help manage high triglycerides, a risk factor for heart disease.
- What could go wrong
- This is an early Phase 1 trial with only 24 participants, so safety and effectiveness are not yet established. The drug may not lower triglycerides as hoped or may cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 24 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: 1\. Males or females aged ≥18 and ≤55 years at the time of screening; 2. Body mass index (BMI) ≥18.0 and ≤35.0 kg/m² at the time of screening, with female participants weighing \>45 kg and male participants weighing \>50 kg; 3. Fasting serum triglyceride (TG) level TG \> 80 mg/dL (0.90 mmol/L) during screening; 4. Fasting LDL-C level ≥ 70 mg/dL (1.81 mmol/L) during screening; Exclusion criteria: 1. History or presence of clinically significant diseases/abnormality, or with clinically significant symptoms/signs, or self-reported diseases, unsuitable for enrollement in the judgement of the investigator. 2\. Fasting blood glucose ≥7.0 mmol/L or HbA1c ≥6.5% during screening. 3. Use of any lipid-lowering treatment (e.g., drugs lowering LDL-C or TG), including but not limited to statins, ezetimibe, fibrates, omega-3 fatty acids, nutritional supplements, or other treatment regimens altering serum lipids within 30 days prior to screening, or use of any ASO or siRNA therapies lowering serum lipids within 12 months prior to screening.. 4\. Use of investigational drugs or instruments within 3 months prior to screening , or plans to participate in other clinical trials during this study. 5. Clinical laboratory parameters during screening meeting any of the following criteria: 1. ALT and/or AST \>1.5 × ULN 2. ALT and/or AST \> ULN and ≤1.5 × ULN, deemed clinically significant and unsuitable for participation in the clinical trial by the investigator 3. INR \> ULN, deemed clinically significant and unsuitable for participation in the clinical trial by the investigator 4. Estimated glomerular filtration rate (eGFR) \<90 mL/min/1.73 m2 (using MDRD formula) 5. Other examination abnormalities deemed clinically significant and unsuitable for participation in the clinical trial by the investigator
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
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Genom att skicka in godkänner du våra Användarvillkor
Locations
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Peking University Third Hospital
Beijing, Beijing Municipality, 100000, China
Contact Email: •••••@•••••
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