Simple furosemide test may predict kidney decline in ICU
NCT ID NCT06765031
First seen Jun 25, 2026 · Last updated Aug 06, 2026 · Updated 3 times
Summary
This study tests whether a furosemide stress test can predict if acute kidney injury will get worse in ICU patients. Researchers will give furosemide to 140 patients and measure urine output over 2 hours. The goal is to see if the test can identify who will need dialysis, helping doctors make faster decisions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- furosemide
- What this could lead to
- If successful, this test could help doctors predict which ICU patients with acute kidney injury will worsen and need dialysis, enabling earlier treatment decisions.
- What could go wrong
- This is a small, early-stage study (140 participants) testing a diagnostic tool, not a treatment. The test may not accurately predict outcomes in all patients, and results may not apply to broader populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
121 people
The number who actually took part.
- Started
-
Nov 2024
- Finished
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Mar 2026
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Those who meet KDIGO AKI stage 1 and stage 2 criteria in the first 24 hours 2. Those with sufficient fluid volume (CVP≥6 cmH20) 3. Female and male patients over the age of 18 will be included in the study Exclusion Criteria: 1. Pregnant patients 2. Hospitalization due to intoxication 3. Liver or kidney transplant 4. Glomerular filtration rate below 30 ml/min/1.73m2 5. Active bleeding 6. Patients with obstructive uropathy 7. Patients in need of urgent RRT (K≥6.6 meq/L, pH\<7.15, pulmonary edema due to fluid overload, uremic complications) 8. Patients evaluated as KDIGO AKI stage 3 9. Patients who have received RRT in the last 30 days 10. Patients with CKD diagnosis 11. Patients with pulmonary embolism 12. Hypoalbuminemia≥2.5 g/dl, 13. Patients receiving cephalosporin treatment will be excluded from the sample.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Gulhane Training and Research Hospital
Ankara, keçiören, 06010, Turkey (Türkiye)
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