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Melatonin-Sprayed fruits: a new superfood?

NCT ID NCT07192835

Knowledge-focused Sponsor: Universidad Miguel Hernandez de Elche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether treating fruits like lemons, blood oranges, and cherries with melatonin before harvest helps the body absorb more healthy plant compounds. Twenty-two healthy adults drank juice from treated or untreated fruits and provided urine samples to measure absorption. The goal is to see if this simple farming step could make fruits even healthier.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Melatonin-treated fruit juice (lemon, blood orange, or sweet cherry)
What this could lead to
If successful, this could show that preharvest melatonin treatment of fruits enhances the body's uptake of beneficial plant compounds, potentially improving dietary strategies for health.
What could go wrong
This is a small, early-stage study with only 22 healthy participants, so results may not apply to the general population. The focus is on absorption, not on treating any disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

22 people

The number who actually took part.

Started

Mar 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy adults aged 18-65 years * Body mass index (BMI) between 18.5 and 24.9 kg/m² * Non-smokers * No chronic diseases (such as diabetes, cardiovascular disease, or cancer) * Not taking regular medication * Willing to follow a diet low in phenolic compounds and melatonin during the study periods * Able and willing to provide urine samples according to study instructions Exclusion Criteria: * Presence of chronic diseases or metabolic disorders * Use of medications that could affect metabolism or absorption of compounds * Smoking or use of nicotine products * Allergies or intolerance to citrus fruits or cherries * Pregnancy or breastfeeding * Inability or unwillingness to comply with study procedures or dietary restrictions

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dietary bioavailability Healthy Melatonin Phenolic compounds Plant extracts

Contacts and locations

Locations

  • University Miguel Hernandez

    Orihuela, Alicante/Alacant, 03312, Spain

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