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Frozen shoulder combo shot shows small extra benefit in motion

NCT ID NCT07183436

Symptom relief Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding hyaluronic acid to a ketorolac injection helps frozen shoulder more than ketorolac alone. Fifty-six adults with frozen shoulder received one shot of either the combination or just ketorolac, then followed a rehab program. After 24 weeks, both groups had similar pain and function improvements, but the combination group gained a little more shoulder rotation and adduction. Both treatments were safe.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hyaluronic acid and ketorolac injection
What this could lead to
If the combination proves superior in larger studies, it could offer a slightly better option for improving shoulder rotation in frozen shoulder patients.
What could go wrong
This was a small, single-center trial with only 56 participants. The added benefit was modest and limited to certain movements, so the combination may not be meaningfully better than ketorolac alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

56 people

The number who actually took part.

Started

Nov 2023

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Eligible participants were adults diagnosed with adhesive capsulitis defined by limitation of shoulder motion ≥25 degrees in at least two planes compared to the contralateral side Inclusion Criteria: * Adults aged 18-70 years * Symptom duration of 1-12 months * Provision of informed consent. Exclusion Criteria: * History of trauma or prior surgery to the affected shoulder * Bilateral adhesive capsulitis * Uncontrolled diabetes (HbA1C \> 7%) * Abnormal thyroid function * Prior intra-articular injection in the affected shoulder * Full-thickness rotator cuff tear on imaging * History of gastrointestinal bleeding * Known allergy to hyaluronic acid or NSAIDs * Systemic conditions affecting joint pain (e.g., SLE, rheumatoid arthritis, osteoarthritis) * Neurological disorders affecting muscle strength or sensation coagulopathy or bleeding disorders withdrawal or refusal of consent at any time

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Conditions

The condition(s) this trial relates to.

bursitis frozen shoulder Shoulder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adhesive capsulitis of the shoulder

Contacts and locations

Locations

  • Faculty of Medicine Ramathibodi Hospital, Mahidol University

    Bangkok, 10400, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.