Frozen shoulder relief: combo injection shows small edge over standard care
NCT ID NCT07183436
First seen Sep 30, 2025 · Last updated Jun 23, 2026 · Updated 29 times
Summary
This study tested whether adding hyaluronic acid to a ketorolac injection helps frozen shoulder more than ketorolac alone. Fifty-six adults with frozen shoulder received one injection of either the combination or just ketorolac, then followed a rehab program. Both groups improved significantly in pain and function, but the combination group had slightly better gains in shoulder rotation and adduction. The treatments were safe and well tolerated.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Faculty of Medicine Ramathibodi Hospital, Mahidol University
Bangkok, 10400, Thailand
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyaluronic acid and ketorolac injection
What this could lead to
If adding hyaluronic acid proves consistently better, it could become a standard option for improving shoulder motion in frozen shoulder patients.
What could go wrong
This is a small, single-center trial. The added benefit was modest and limited to certain movements, so the combination may not be meaningfully better than ketorolac alone for most people.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.