Earlobe crease may reveal hidden heart danger in smokers
NCT ID NCT07427745
First seen Feb 25, 2026 · Last updated Apr 29, 2026 · Updated 6 times
Summary
This study examined the link between a diagonal earlobe crease (Frank's sign) and smoking in 404 adults aged 40-59. Researchers compared current, former, and non-smokers to see if the crease was more common in smokers, as it may indicate hidden blood vessel damage. The goal is to help doctors quickly spot people at higher risk for heart disease using a simple, non-invasive check.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Samsun University Training and Research Hospital (Samsun City Hospital)
Samsun, Turkey (Türkiye)
Conditions
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