New combo therapy for tough prostate cancer shows promise in early trial

NCT ID NCT03737370

Completed Disease control Sponsor: Tufts Medical Center Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 25, 2026 · Updated 28 times

Summary

This early-phase study tested a combination of two treatments—a chemotherapy drug (docetaxel) given in smaller, split doses and a targeted radiation therapy (radium-223)—in 43 men with advanced prostate cancer that no longer responds to hormone therapy. The main goal was to find the safest dose and understand side effects. The study was completed and helps guide future research on this combination.

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Contacts and locations

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Locations

Henry Ford Health System

Detroit, Michigan, 48202, United States
Lahey Hospital & Medical Center

Boston, Massachusetts, 01805, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States

Conditions

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METASTATIC CASTRATE RESISTANT PROSTATE CANCER