Ultrasound zaps a new brain spot to quiet Parkinson's tremors

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Confirmed diagnosis of Parkinson's disease * Resting tremor score (MDS-UPDRS III 3.17 Rest Tremore Amplitude (RUE or LUE)) ≥ 2 * Between the ages of 40-80 years * Hoehn and Yahr stage between 1-3 (mild to moderate PD) in the "ON" state * Patients who are willing to have a partial (\~8 cm diameter circular area above the ear) hair shaving. Exclusion Criteria: * Atypical Parkinsonism * History of essential tremor * Dementia preventing informed consent * Change in Parkinson's medication with the last 2 weeks * Neurological disease other than PD, including Alzheimer's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, a brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma * Unstable medical conditions or serious disease/conditions (e.g., cancer undergoing active treatment, poorly controlled diabetes) * Concurrent treatment for PD with Duodopa * Concurrent treatment for PD with deep brain stimulation (DBS) * Thickness of the temporal bone \< 7 mm * Individuals should also not participate if they have any of the following contraindications for undergoing fMRI scanning: * Cardiac pacemaker, wires, or defibrillator * Metal in eye or orbit, including the history of any eye injury involving metal fragments and increased risk due to (history of) working as a metal worker (grinding, machining, or welding) * Ferromagnetic aneurysm clip * Possibility of pregnancy * Artificial heart valve * Ear or eye implant, including cochlear implant * Brain aneurysm clip * Implanted drug infusion pump * Electrical stimulator to nerves or bones * Coil, catheter, or filter in any blood vessel * Orthopedic hardware (artificial joint, plate, screw, rod) * Other metallic prostheses * Shrapnel, bullets, or other metal fragments * Surgery, piercings or tattoos (including tattooed eyeliner) in the last six weeks * Medication releasing skin patches (i.e. nicotine, birth control, nitroglycerine) * History of claustrophobia