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Wake-up drug may speed recovery after hip surgery in seniors

NCT ID NCT05939674

Symptom relief Sponsor: Pusan National University Yangsan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether giving flumazenil, a drug that reverses the effects of remimazolam, helps elderly patients wake up faster after hip surgery. 24 patients over 65 will be randomly assigned to receive flumazenil or a placebo right after surgery. Researchers will measure how quickly they open their eyes and can be taken off the breathing tube.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
flumazenil
What this could lead to
If it works, this could show that giving flumazenil routinely after remimazolam anesthesia helps elderly patients wake up faster after hip surgery.
What could go wrong
This is a very small, early-stage trial with only 24 participants. It may not find a clear benefit, and flumazenil can cause side effects like agitation or seizures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients over 65 years old scheduled for hip joint surgery Exclusion Criteria: * Patients with impaired consciousness or delirium before surgery * Patients who are hemodynamically unstable before surgery * Patients with a history of neurological or neuromuscular disorders or use of medications that affect neurological or neuromuscular function * Patients who have taken sedatives (anti-anxiety medications, antipsychotics, antidepressants, sleep aids) within the past 24 hours * Patients with known allergy to benzodiazepine, flumazenil * Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption * Patients with hypersensitivity to Dextran40 * Patients who have been taking benzodiazepine for long term * Patients with end stage renal disease requiring hemodialysis * Patients with history of acute angle glaucoma * Patients with alcohol or substance dependence * ASA classification 4 or 5

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Elderly patients Flumazenil adverse reaction Hip joint Remimazolam

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Pusan National University Yangsan Hospital

    RECRUITING

    Yangsan, Gyeongsangnam-do, 50612, South Korea

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