New ultrasound method may help doctors give fluids only when needed
NCT ID NCT07202637
First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 3 times
Summary
This study tests whether a heart ultrasound measurement (sub-pulmonary VTI) can predict if a critically ill patient will benefit from IV fluids. Researchers will give 500 mL of fluid to 205 patients with signs of low blood volume and compare the new measure to a standard one. If accurate, it could offer a simpler way to guide fluid therapy, especially in patients where standard views are hard to obtain.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- crystalloid fluid bolus
- What this could lead to
- If successful, this could give doctors a new, reliable way to decide which critically ill patients need fluids, potentially improving care and avoiding unnecessary fluid administration.
- What could go wrong
- This is an early observational study, not a treatment trial. The new ultrasound measure may not prove accurate enough to replace current methods, and results may not apply to all patient groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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205 people
The number who actually took part.
- Started
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Nov 2024
- Finished
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Feb 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
In patients with suspected hypovolemia, a cardiac ultrasound is performed as part of routine care. A patient is eligible if it is possible to measure both sub-aortic VTI (gold standard) and sub-pulmonary VTI in one of the two echocardiographic windows described in the literature (parasternal short-axis or subcostal).
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal. * Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver. * Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion. Exclusion Criteria: * Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) \< 30%. * Severe right ventricular dysfunction defined by TAPSE \< 12 mm. * Cardiac arrhythmia or atrial fibrillation. * Abdominal compartment syndrome. * Amputation of one or both lower limbs. * Intracranial hypertension. * Pregnant women (ruled out by systematic pregnancy test at ICU admission). * Minors.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hopital Caremeau Nimes
Nîmes, 30029, France
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Service de réanimation polyvalente - Hopital Nord
Marseille 15, 13015, France
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