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New breathing technique during lung surgery could cut complications

NCT ID NCT07623395

Knowledge-focused Sponsor: Cantonal Hospital of St. Gallen Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 4 times

Summary

This study tests a new ventilation method called flow-controlled ventilation (FCV) during lung surgery, comparing it to standard volume-controlled ventilation. About 140 adults having elective thoracic surgery with one-lung ventilation will take part. The goal is to see if FCV is feasible and safe in a multi-center setting, and to gather data for a larger future trial on reducing postoperative lung complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * aged ≥ 18 years; and * scheduled for elective open, video- or robot-assisted thoracic surgery with one-lung ventilation using a double-lumen tube (DLT); and * able to give written informed consent. Exclusion Criteria: * body weight \< 40 kg; * ASA score IV - VI; * lung separation with other method than DLT (e.g. difficult airway, tracheostomy); * previous lung surgery; * COPD GOLD grades III and IV, lung fibrosis, documented bullae, severe emphysema, pneumothorax; * uncontrolled asthma; * Heart failure NYHA Grade 3 and 4, Coronary Heart Disease CCS Grade 3 and 4; * documented pulmonary arterial hypertension \>25 mmHg mPAP at rest or \>40mmHg syst. (estimated by ultrasound) or \>20 mmHg mPAP measured by right heart catheterization, or pulmonary vascular resistance \> 2.0 Wood units; * documented or suspected neuromuscular disease (thymoma, myasthenia, myopathies, muscular dystrophies, others); * planned mechanical ventilation after surgery; * bilateral procedures; * surgery in prone position; * persistent hemodynamic instability, intractable shock; * intracranial injury or tumor; * esophagectomy, pleural surgery only, sympathectomy surgery only, chest wall surgery only, mediastinal surgery only, lung transplantation; * presence before induction of anesthesia of one of the adverse events, listed as postoperative pulmonary complications (aspiration, moderate respiratory failure, infiltrates, pulmonary infection, atelectasis, cardiopulmonary oedema, pleural effusion, pneumothorax, pulmonary embolism, purulent pleuritis, lung hemorrhage); * documented preoperative hypercapnia \> 45mmHg (6kPa) * previous enrolment in the current study; * being the study investigator of this study, his/her family members, employees and other dependent persons; * if female and of childbearing potential, known pregnancy or a positive urine pregnancy test (confirmed by a positive serum pregnancy test), or lactating; or * no written informed consent.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation Postoperative pulmonary complications (PPCS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    7 sites in 4 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Department of Anaesthesiology University Hospital Basel

    Basel, Switzerland

  • Department of Anaesthesiology, HOCH Health Ostschweiz, Cantonal Hospital St. Gallen

    Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

  • Department of Anaesthesiology, Hospital Foch

    Paris, France

  • Department of Anaesthesiology, Medical University Graz

    Graz, Austria

  • Department of Anaesthesiology, Medical University Innsbruck

    Innsbruck, Tyrol, 6020, Austria

  • Department of Anaesthesiology, Stadtspital Triemli

    Zurich, Switzerland

  • Ruhr Universität Bergmannsheil

    Bochum, Germany

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