Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New hope for rare lung cancer: targeted drug trial launches

NCT ID NCT07185997

Disease control Sponsor: ArriVent BioPharma, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 5 times

Summary

This study tests a new drug, firmonertinib, against two standard treatments for people with advanced non-small-cell lung cancer that has certain rare genetic changes (EGFR PACC mutations). About 480 participants who have not had prior treatment for advanced disease will be randomly assigned to receive firmonertinib or a standard drug. The goal is to see if firmonertinib can better delay cancer growth or improve response rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 480 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Eligibility Criteria: * Histologically or cytologically documented, locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) not amenable to curative surgery or radiotherapy. * Documented results of the presence of an Epidermal Growth Factor Receptor (EGFR) PACC mutation in tumor tissue or blood from local testing. * No prior systemic anticancer therapy regimens received for locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) including prior treatment with any Epidermal Growth Factor Receptor (EGFR)-targeting agents (e.g., previous (EGFR) TKIs, monoclonal antibodies, or bispecific antibodies). * Patients who have received prior neo-adjuvant and/or adjuvant chemotherapy, immunotherapy, or chemo radiotherapy for non-metastatic disease must have experienced a treatment free interval of at least 12 months. * Patients with asymptomatic CNS metastases are eligible.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Advanced non-small cell lung cancer are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

bronchial neoplasm lung neoplasm non-small cell lung carcinoma respiratory tract neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Advanced non-small cell lung cancer EGFR P-loop and alpha C-helix compressing EGFR pacc EGFR uncommon mutations Metastatic non-small cell lung cancer Non-small cell lung cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    118 sites in 17 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Hospital of Nantong University

    RECRUITING

    Nantong, Jiangsu, 226001, China

  • Aichi Cancer Center

    RECRUITING

    Nagoya, Aichi-ken, 464-8681, Japan

  • Alberta Health Services, Tom Baker Cancer Centre

    RECRUITING

    Calgary, Alberta, T2N 4N2, Canada

  • Anatalya Province

    RECRUITING

    Antalya, 07050, Turkey (Türkiye)

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

  • Athens Medical Center S.A., European Interbalkan Medical Center

    RECRUITING

    Thessaloniki, 570 01, Greece

  • Austin Health

    RECRUITING

    Heidelberg, Victoria, 3084, Australia

  • BC Cancer Vancouver Centre

    RECRUITING

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Beijing Chest Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, 101149, China

  • Blacktown Cancer and Haematology Centre

    RECRUITING

    Blacktown, New South Wales, 2148, Australia

  • Brampton Civic Hospital, William Osler Health Centre

    RECRUITING

    Brampton, Ontario, L6R 3J7, Canada

  • Cancer Hospital of Shantou University Medical College

    RECRUITING

    Shantou, Guangdong, 515000, China

  • Centre Francois Baclesse

    RECRUITING

    Caen, Calvados, 14076, France

  • Centre Leon-Berard

    RECRUITING

    Lyon, 69373, France

  • China shenyang the tenth People's Hospital

    RECRUITING

    Shenyang, Liaoning, 110044, China

  • Chonnam National University Hwasun Hospital

    RECRUITING

    Hwasun, Jeollanam-do, 58128, South Korea

  • Chris O'Brien Lifehouse

    RECRUITING

    Camperdown, New South Wales, 2050, Australia

  • Chulabhorn Hospital

    RECRUITING

    Lak Si, Bangkok, 10210, Thailand

  • Curie Oncology (Farrer)

    RECRUITING

    Singapore, 217562, Singapore

  • Faculty of Medicine Vajira Hospital, Navamindradhiraj University

    RECRUITING

    Bangkok, 10300, Thailand

  • Fox Chase Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19111, United States

  • Fujita Health University Hospital

    RECRUITING

    Toyoake, Aichi-ken, 470-1192, Japan

  • Gachon University Gil Medical Center

    RECRUITING

    Incheon, 21565, South Korea

  • GenesisCare North Shore Health Hub

    RECRUITING

    St Leonards, New South Wales, 2065, Australia

  • Gulhane Training and Research Hospital

    RECRUITING

    Ankara, 06010, Turkey (Türkiye)

  • Harbin Medical University Cancer Hospital

    RECRUITING

    Harbin, Heilongjiang, 150081, China

  • Henry Dunant Hospital Center

    RECRUITING

    Athens, 115 26, Greece

  • Henry Ford Cancer Institute

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Hopital Larrey

    RECRUITING

    Toulouse, Occitanie, 31059, France

  • Hopital Nord Guilaume-et-Rene-Laennec CHU de Nantes

    RECRUITING

    Saint-Herblain, 44093, France

  • Hospices Civil de Lyon

    RECRUITING

    Bron, Auvergne-Rhône-Alpes, 69500, France

  • Hospital Clinic de Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Kuala Lumpur

    RECRUITING

    Kuala Lumpur, WP Kuala Lumpur, 50586, Malaysia

  • Hospital Nord de Marseille

    RECRUITING

    Marseille, Bouches-du-Rhone, 13915, France

  • Hospital QuironSalud Malaga

    RECRUITING

    Málaga, 29004, Spain

  • Hospital Universitari Son Espases

    RECRUITING

    Palma, Balearic Islands, 07120, Spain

  • Hospital Universitario Central de Asturias

    RECRUITING

    Oviedo, 33011, Spain

  • Hospital Universitario y Politecnico La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Humanity and Health Clinical Trial Centre

    RECRUITING

    Central, Hong Kong

  • Hyogo Cancer Center

    RECRUITING

    Akashi-shi, Hyōgo, 673-8558, Japan

  • Illinois Cancer Specialists

    RECRUITING

    Arlington Heights, Illinois, 60005, United States

  • Insitut de Canderologie d I'Ouest

    RECRUITING

    Saint-Herblain, 44805, France

  • Istinye University Bahcesehir Liv Hospital

    RECRUITING

    Istanbul, 34517, Turkey (Türkiye)

  • Istituto Europeo di Oncologia (IEO)

    RECRUITING

    Milan, 20141, Italy

  • Jiangsu Province Hospital

    RECRUITING

    Nanjing, Jiangsu, 210029, China

  • Kaiser Permanente Medical Center

    RECRUITING

    Vallejo, California, 94589, United States

  • Kangbuk Samsung Hospital

    RECRUITING

    Seoul, 03181, South Korea

  • Kansai Medical University Hospital

    RECRUITING

    Hirakata-shi, Osaka, 573-1191, Japan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, 807, Taiwan

  • Kurume University Hospital

    RECRUITING

    Kurume-Shi, Fukuoka, 830-0011, Japan

  • Kyung Hee University Hospital

    RECRUITING

    Seoul, 02447, South Korea

  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

    RECRUITING

    New York, New York, 10016, United States

  • Mahidol University - Siriraj Hospital

    RECRUITING

    Bangkoknoi, Bangkok, 10700, Thailand

  • Medical Park Florya Hospital

    RECRUITING

    Istanbul, 34295, Turkey (Türkiye)

  • Memorial Ankara Hospital

    RECRUITING

    Ankara, Ankara, 06520, Turkey (Türkiye)

  • Miyagi Cancer Center

    RECRUITING

    Natori-shi, Miyagi, 981-1293, Japan

  • Nanjing Drum Tower Hospital

    RECRUITING

    Nanjing, Jiangsu, 210031, China

  • National Cancer Center Hospital

    RECRUITING

    Chuo-ku, Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East

    RECRUITING

    Kashiwa, Chiba, 277-8577, Japan

  • National Cancer Centre Singapore

    RECRUITING

    Singapore, 168583, Singapore

  • National Hospital Organization Hokkaido Cancer Center

    RECRUITING

    Sapporo, Hokkaido, 003-0804, Japan

  • National Taiwan University Cancer Center

    RECRUITING

    Taipei, 106, Taiwan

  • Niigata Cancer Center Hospital

    RECRUITING

    Niigata, Niigata, 951-8566, Japan

  • Nippon Medical School Hospital

    RECRUITING

    Bunkyo-ku, Tokyo, 113-8603, Japan

  • Northwell Health/R.J. Zuckerberg Cancer Center

    RECRUITING

    Lake Success, New York, 11042, United States

  • Ohio State University Hospitals

    RECRUITING

    Columbus, Ohio, 43210, United States

  • OncoCar Cancer Centre

    RECRUITING

    Petaling Jaya, Selangor, 47810, Malaysia

  • Peking University People's Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100044, China

  • Prince of Songkla Hospital

    RECRUITING

    Hat Yai, Changwat Songkhla, 90110, Thailand

  • Prince of Wales Hospital

    RECRUITING

    Shatin, New Territories, Hong Kong

  • Princess Margaret Cancer Centre - University Health Network

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

  • Profile of The Third Xiangya Hospital of Central South University

    RECRUITING

    Changsha, Hunan, 410013, China

  • Providence St. Joseph Hospital

    RECRUITING

    Orange, California, 92868, United States

  • Queen Mary Hospital

    RECRUITING

    Hong Kong, Hong Kong, 000000, Hong Kong

  • SOC Oncologia Medica e dei Tumori Immuno-correlati

    RECRUITING

    Aviano, 33081, Italy

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • Shanghai Chest Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 20030, China

  • Shanxi Cancer Hospital

    RECRUITING

    Taiyuan, Shanxi, 30009, China

  • Shenandoah Oncology, P.C.

    RECRUITING

    Winchester, Virginia, 22601, United States

  • Sichuan Cancer Hospital

    RECRUITING

    Chengdu, Sichuan, 610213, China

  • St. Jude Medical Center

    RECRUITING

    Fullerton, California, 92835, United States

  • Sunnybrook Research Institute

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

  • Swedish Cancer Institute

    RECRUITING

    Edmonds, Washington, 98026, United States

  • Taichung Veterans General Hospital

    RECRUITING

    Taichung, 407219, Taiwan

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 11217, Taiwan

  • Tan Tok Seng Hospital

    RECRUITING

    Singapore, 308433, Singapore

  • Texas Oncology

    RECRUITING

    Dallas, Texas, 75246, United States

  • The Affiliated Hospital of Inner Mongolia Medical University

    RECRUITING

    Hohhot, Inner Mongolia, 010030, China

  • The Affiliated Hospital of Qingdao University

    RECRUITING

    Qingdao, Shandong, 276001, China

  • The Catholic University of Korea, St. Vincent's Hospital

    RECRUITING

    Suwon, Gyeonggi-do, 16247, South Korea

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, England, M20 4BX, United Kingdom

  • The First Affiliated Hospital of Henan Medical University

    RECRUITING

    Xinxiang, Henan, 453100, China

  • The First Affiliated Hospital of Henan University of Science & Technology

    RECRUITING

    Luoyang, Henan, 47100, China

  • The First Affiliated Hospital of Nanchang University

    RECRUITING

    Nanchang, Jiangxi, 330200, China

  • The First Affiliated Hospital of Zhengzhou University

    RECRUITING

    Zhengzhou, Henan, 450008, China

  • The First People's Hospital of Foshan

    RECRUITING

    Foshan, Guangdong, 528000, China

  • The Fourth Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, Hebei, 50011, China

  • The Ottawa Hospital Cancer Centre

    RECRUITING

    Ottawa, Ontario, K1H 8L6, Canada

  • The Royal Marsden NHS Foundation Trust

    RECRUITING

    London, SW3 6JJ, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Thoracic General Hospital of Athens I Sotiria

    RECRUITING

    Thessaloniki, 570 01, Greece

  • Tianjin Chest Hospital

    RECRUITING

    Tianjin, Tianjin Municipality, 300222, China

  • Tianjin Medical University Cancer Institute & Hospital

    RECRUITING

    Tianjin, Tianjin Municipality, 300222, China

  • Tokyo Metropolitan Komagome Hospital

    RECRUITING

    Bunkyō-Ku, Tokyo, 113-8677, Japan

  • UCSF Medical Center-Mission Bay

    RECRUITING

    San Francisco, California, 94158, United States

  • USC/Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

  • Union Hospital Tongji Medical College Huazhong University Of Science And Technology

    RECRUITING

    Wuhan, Hubei, 430000, China

  • University College London Hospitals NHS Foundation Trust

    RECRUITING

    London, England, NW1 2PG, United Kingdom

  • University General Hospital Attikon - General Hospital of West Attica H AGIA VARVARA

    RECRUITING

    Athens, 124 62, Greece

  • University of California Davis Comprehensive Cancer Center

    RECRUITING

    Sacramento, California, 95817, United States

  • University of Colorado Health

    RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Illinois Hospital and Health Sciences Systems

    RECRUITING

    Chicago, Illinois, 60612, United States

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • Virginia Cancer Specialists

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Weifang People's Hospital

    RECRUITING

    Weifang, Shandong, 261057, China

  • Yunnan Cancer Hospital

    RECRUITING

    Kunming, Yunnan, 650118, China

  • Zhejiang Cancer Hospital

    RECRUITING

    Hangzhou, Zhejiang, 310022, China

  • Zhongshan Hospital Xiamen University

    RECRUITING

    Xiamen, Fujian, 361004, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.