New hope for rare lung cancer: targeted drug trial launches

NCT ID NCT07185997

Recruiting now Disease control Sponsor: ArriVent BioPharma, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 23 times

Summary

This study tests a new drug, firmonertinib, against two standard treatments for people with advanced non-small-cell lung cancer that has specific rare genetic changes (EGFR PACC mutations). About 480 participants who have not had prior treatment for advanced disease will be randomly assigned to receive firmonertinib or a standard drug. The goal is to see if firmonertinib can better delay cancer growth or improve response rates.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Aichi Cancer Center
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Athens Medical Center S.A., European Interbalkan Medical Center
RECRUITING

Thessaloniki, 570 01, Greece
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Blacktown Cancer and Haematology Centre
RECRUITING

Blacktown, New South Wales, 2148, Australia
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, Jeollanam-do, 58128, South Korea
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Curie Oncology (Farrer)
RECRUITING

Singapore, 217562, Singapore
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Gachon University Gil Medical Center
RECRUITING

Incheon, 21565, South Korea
GenesisCare North Shore Health Hub
RECRUITING

St Leonards, New South Wales, 2065, Australia
Henry Dunant Hospital Center
RECRUITING

Athens, 115 26, Greece
Hospital Clinic de Barcelona
RECRUITING

Barcelona, 08036, Spain
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, WP Kuala Lumpur, 50586, Malaysia
Hospital QuironSalud Malaga
RECRUITING

Málaga, 29004, Spain
Hospital Universitari Son Espases
RECRUITING

Palma, Balearic Islands, 07120, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33011, Spain
Hospital Universitario y Politecnico La Fe
RECRUITING

Valencia, 46026, Spain
Humanity and Health Clinical Trial Centre
RECRUITING

Central, Hong Kong
Hyogo Cancer Center
RECRUITING

Akashi-shi, Hyōgo, 673-8558, Japan
Illinois Cancer Specialists
RECRUITING

Arlington Heights, Illinois, 60005, United States
Istituto Europeo di Oncologia (IEO)
RECRUITING

Milan, 20141, Italy
Kaiser Permanente Medical Center
RECRUITING

Vallejo, California, 94589, United States
Kangbuk Samsung Hospital
RECRUITING

Seoul, 03181, South Korea
Kansai Medical University Hospital
RECRUITING

Hirakata-shi, Osaka, 573-1191, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, 807, Taiwan
Kurume University Hospital
RECRUITING

Kurume-Shi, Fukuoka, 830-0011, Japan
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Miyagi Cancer Center
RECRUITING

Natori-shi, Miyagi, 981-1293, Japan
National Cancer Center Hospital
RECRUITING

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore
National Hospital Organization Hokkaido Cancer Center
RECRUITING

Sapporo, Hokkaido, 003-0804, Japan
Niigata Cancer Center Hospital
RECRUITING

Niigata, Niigata, 951-8566, Japan
Nippon Medical School Hospital
RECRUITING

Bunkyo-ku, Tokyo, 113-8603, Japan
Queen Mary Hospital
RECRUITING

Hong Kong, 000000, Hong Kong
SOC Oncologia Medica e dei Tumori Immuno-correlati
RECRUITING

Aviano, 33081, Italy
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Shenandoah Oncology, P.C.
RECRUITING

Winchester, Virginia, 22601, United States
Sunnybrook Research Institute
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Taichung Veterans General Hospital
RECRUITING

Taichung, 407219, Taiwan
Tan Tok Seng Hospital
RECRUITING

Singapore, 308433, Singapore
Texas Oncology
RECRUITING

Dallas, Texas, 75246, United States
The Catholic University of Korea, St. Vincent's Hospital
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
The Christie NHS Foundation Trust
RECRUITING

Manchester, England, M20 4BX, United Kingdom
The Ottawa Hospital Cancer Centre
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Thoracic General Hospital of Athens I Sotiria
RECRUITING

Thessaloniki, 570 01, Greece
Tokyo Metropolitan Komagome Hospital
RECRUITING

Bunkyō-Ku, Tokyo, 113-8677, Japan
UCSF Medical Center-Mission Bay
RECRUITING

San Francisco, California, 94158, United States
USC/Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States
University College London Hospitals NHS Foundation Trust
RECRUITING

London, England, NW1 2PG, United Kingdom
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Illinois Hospital and Health Sciences Systems
RECRUITING

Chicago, Illinois, 60612, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States

Conditions

Explore the condition pages connected to this study.

ADVANCED NON-SMALL-CELL LUNG CANCER EGFR P-LOOP AND ALPHA C-HELIX COMPRESSING EGFR P-LOOP AND ALPHA C-HELIX COMPRESSING EGFR PACC EGFR PACC EGFR UNCOMMON MUTATIONS METASTATIC NON-SMALL CELL LUNG CANCER NON SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER