Small study aims to perfect fluid dosing for safer C-Sections
NCT ID NCT07324512
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing different amounts of IV fluid given during spinal anesthesia for planned C-sections to find the smallest dose that prevents dangerously low blood pressure in 90% of women. 45 healthy pregnant women at term will receive a specific fluid volume right after the spinal injection, and the dose will be adjusted for each next participant based on results. The goal is to improve safety for both mother and baby without using more fluid than needed.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- intravenous crystalloid fluid (balanced salt solution)
- What this could lead to
- If successful, this could establish a standard fluid dose to prevent dangerous drops in blood pressure during C-sections, making the procedure safer for mothers and newborns.
- What could go wrong
- This is a very small, early-phase dose-finding study (45 participants) with no comparison group. Results may not apply to all pregnant women, and the optimal dose may still fail in some cases.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 45 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Pregnant adults ≥19 years scheduled for elective cesarean delivery under spinal anesthesia * Term pregnancy (≥37 weeks' gestation) Exclusion Criteria: * Emergency cesarean delivery * Hypertensive disorders of pregnancy (preeclampsia/eclampsia) or hypertension * Multiple gestation * Body weight \<50 kg or BMI \>35 kg/m² * Renal impairment or eGFR ≤90 mL/min/1.73 m² * Heart failure or other heart disease * History of bronchial asthma or other pulmonary disease
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.