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New heart scan could save time and money for chest pain patients

NCT ID NCT03187639

Diagnosis Sponsor: University Hospital Southampton NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a special CT scan called FFRct can help doctors better manage stable chest pain compared to standard guidelines. About 1,400 adults with chest pain but no other major heart issues took part. The goal was to see if using FFRct as the first test reduces the need for extra procedures and lowers healthcare costs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
FFRct (fractional flow reserve computed tomography)
What this could lead to
If successful, this could make diagnosing and managing stable chest pain more efficient, reducing unnecessary procedures and costs.
What could go wrong
This is a completed Phase 4 trial, but results may not apply to all patients, and the test may not always be accurate or available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

1,400 people

The number who actually took part.

Started

Dec 2017

Finished

Jun 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged over 18 * Primary symptom of chest pain * No contraindication to CTA * Willing and able to provide written informed consent Exclusion Criteria: * Atrial fibrillation of new onset or when rate control has been difficult * Known bigemini/trigeminy * Prior CABG surgery * Allergic to contrast * Advanced renal impairment * Significant valve disease (severe aortic stenosis or regurgitation; severe mitral regurgitation) * Life expectancy \<12 months * Inclusion in another trial without prior agreement with CI

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease

Contacts and locations

Locations

  • Southampton Clinical Trials Unit

    Southampton, Hampshire, SO16 6YD, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.