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Frozen hope: new study aims to save fertility for young cancer patients

NCT ID NCT06063551

Knowledge-focused Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study collects and freezes testicular tissue from prepubertal boys before they start cancer treatment that has a high risk of causing infertility. The tissue is stored for potential future use to restore fertility and for research to better understand germ cell development. Up to 100 boys will be enrolled at a hospital in Edinburgh, with tissue stored for up to 55 years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help preserve fertility in boys who might otherwise become infertile after cancer treatment.
What could go wrong
This is an early-stage tissue storage study, not a treatment. It is unknown if the frozen tissue can later restore fertility, and the procedure carries surgical risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2016

Expected to finish

Apr 2061

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 day to 18 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Pre- and peripubertal boys * Due to receive cancer treatment that is predicted to have a high risk (\>80%) of infertility * Consent to removal of testicular tissue for storage and research * Unable to produce a semen sample by masturbation Exclusion Criteria: * Participation in study would delay treatment * Too unwell to undergo the procedure * Pre-existing testicular pathology/previous testicular surgery (eg orchidopexy) * Able to produce a semen sample for cryopreservation

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Conditions

The condition(s) this trial relates to.

childhood malignant neoplasm infertility disorder neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Childhood cancer Fertility disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Edinburgh

    RECRUITING

    Edinburgh, Lothian, EH164TJ, United Kingdom

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