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Simple nerve stretch could ease knee arthritis pain without drugs

NCT ID NCT07329205

Symptom relief Sponsor: Prince Sattam Bin Abdulaziz University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a specific nerve-stretching exercise (femoral nerve mobilization) to standard physical therapy can reduce pain and improve function in people with knee osteoarthritis. Fifty patients aged 50 or older with mild to moderate knee arthritis will be randomly assigned to receive either standard therapy alone or standard therapy plus the nerve stretch. Researchers will measure pain, knee function, quality of life, and signs of central sensitization (a heightened pain response) over four weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
femoral nerve mobilization (a physiotherapy technique)
What this could lead to
If it works, this could offer a simple, drug-free way to ease pain and improve daily life for people with early-stage knee osteoarthritis.
What could go wrong
This is a small, early-stage trial with only 50 participants, so results may not apply to everyone. The technique is manual and depends on therapist skill, and benefits may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients aged 50 years or older, diagnosed with KO according to theAmerican College of Rheumatology's criteria with knee pain, and grade I or II on the Kellgren-Lawrence radiographic scale Exclusion Criteria: * individuals suffering from chronic conditions considered to be perpetuating factors (e.g., fibromyalgia) * those with conditions causing lower extremity pain * individuals who had taken analgesics within 24 h before evaluations * those who had undergone corticosteroid or local anesthetic infiltration in the year prior to the study or during the follow-up period * those using substances that could interfere with treatment * those with a previous diagnosis of neuropathy (lumbosacral plexus) or myopathy * those with contraindications to mobilization or exercise, and those with cognitive deficits (dementia, Alzheimer's).

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthristis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Prince Sattam bin Abdulaziz University

    Al Kharj, 16242, Saudi Arabia

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