New study aims to uncover hidden fever culprits in cambodia
NCT ID NCT04034264
First seen Jun 25, 2026 · Last updated Sep 17, 2026 · Updated 17 times
Summary
This study is looking for the germs that cause fevers in Cambodia, especially those spread by insects like mosquitoes. Researchers will use advanced genetic testing to find these germs in blood and nasal samples from 6,500 people. The goal is to better understand what is making people sick and to guide future efforts to diagnose and treat these illnesses.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify unknown causes of fever in Cambodia and guide future studies on vector-borne diseases.
- What could go wrong
- This is an observational study, not a treatment trial. It may not directly benefit participants, and results may take years to impact clinical practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 6,500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2019
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Febrile patients who have documented fever equal to or greater than 38 degrees celsius in previous 24 hours, or those with a highly morbid and/or transmissible pathogen detected using standard clinical tests, who present at a hospital. If there is a highly morbid and/or transmissible pathogen identified from the febrile patient, close contacts will be identified through discussion with the patient.
- Ages
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2 months and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Provision of signed and dated ICF. * Stated willingness to comply with all study procedures. * Male or female, aged at least 2 months * Meets one of the following case definitions: * Febrile patient: has documented fever equal to or greater than 38 degrees celsius in previous 24 hours. * Red flag patient: is an individual with disease relating to a red flag pathogen (see list, below), with confirmed standard laboratory testing (e.g., blood culture, polymerase chain reaction \[PCR\]) for the pathogen in question. * Afebrile close contact: is an afebrile individual who lived in the same household or worked in the same enclosed workspace on a daily basis with a red flag patient at the time they got sick with a known pathogen. * Willing to allow biological samples to be stored for future research and for all de-identified metagenomic sequencing data to be stored in publicly accessible databases. EXCLUSION CRITERIA: * Any underlying, chronic, or current medical condition that, in the opinion of the investigator, would interfere with participation in the study (e.g., inability or great difficulty in drawing blood). * Any febrile individual who has had surgery in the prior month. * Any patient who enrolled and exited this study within 30 days of the initial study blood draw, or afebrile close contact who enrolled and exited within 14 days.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
6 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Kampong Speu Referral Hospital
RECRUITINGChbar Mon, Cambodia
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Kantha Bopha Hospital
RECRUITINGPhnom Penh, Cambodia
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Khmer-Soviet Friendship Hospital
RECRUITINGPhnom Penh, Cambodia
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National Pediatric Hospital
RECRUITINGPhnom Penh, Cambodia
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Preah Kossomak Hospital
RECRUITINGPhnom Penh, Cambodia
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Takeo District Referral Hospital
RECRUITINGTakeo, Cambodia
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