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Can a nerve block and a sedative replace opioids in heart surgery?

NCT ID NCT07749274

Disease control Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial compares two anesthesia strategies for minimally invasive heart surgery: one using a sedative called dexmedetomidine plus an ultrasound-guided nerve block, and the other using conventional opioid-based anesthesia. The goal is to see if the new approach allows patients to wake up and breathe on their own sooner after surgery, while also reducing opioid use and related side effects. Adults aged 18-65 scheduled for certain minimally invasive heart procedures may participate.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine and an ultrasound-guided erector spinae plane block
What this could lead to
If successful, this approach could reduce opioid use and shorten recovery time after minimally invasive heart surgery, potentially leading to faster discharge and fewer opioid-related side effects.
What could go wrong
This is a small, early-stage trial, so results may not apply broadly. The nerve block and drug may not work as hoped, and there are always risks with anesthesia and surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-65 years. Scheduled for elective minimally invasive cardiac surgery (MICS), including: Minimally invasive mitral valve repair or replacement. Minimally invasive aortic valve replacement. Atrial septal defect (ASD) closure. Minimally invasive direct coronary artery bypass (MIDCAB). Left ventricular ejection fraction (LVEF) ≥45%. EuroSCORE II \<4%. American Society of Anesthesiologists (ASA) physical status II or III. Body mass index (BMI) 18-35 kg/m². Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Emergency cardiac surgery. BMI \<18 or \>35 kg/m². Severe pulmonary disease (COPD requiring home oxygen therapy or FEV1 \<50% predicted). Obstructive sleep apnea or anticipated difficult airway. Preoperative intubation, cardiogenic shock, or need for preoperative inotropic/vasopressor support. Known allergy or contraindication to dexmedetomidine, fentanyl, bupivacaine, propofol, or other study medications. Severe hepatic impairment or renal failure requiring dialysis (creatinine clearance \<30 mL/min). Chronic opioid use (\>3 months) or chronic pain requiring long-term analgesics. Contraindications to erector spinae plane block (coagulopathy, platelet count \<100,000/µL, INR \>1.5, anticoagulant therapy, infection at the injection site, or patient refusal). Baseline bradycardia (heart rate \<50 beats/min) or second-/third-degree atrioventricular block without a functioning pacemaker. Known substance abuse disorder

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac disease minimally invasive cardiac surgery postoperative pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Assiut university hospital

    Asyut, Ass, 71515, Egypt