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Hormone implant aimed at saving uteruses after failed ablation – trial pulled

NCT ID NCT05227456

Disease control Sponsor: Saskatchewan Health Authority - Regina Area Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study planned to test whether an etonogestrel implant (Nexplanon) could reduce the need for hysterectomy in women who still had abnormal bleeding or pelvic pain after endometrial ablation. The trial was withdrawn before enrolling any participants, so no data were collected. The implant releases a hormone to control bleeding and pain, but its effectiveness in this specific situation remains unknown.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
etonogestrel implant (Nexplanon)
What this could lead to
If it had worked, this could have offered a way to avoid hysterectomy for women with continued bleeding or pain after endometrial ablation.
What could go wrong
The trial was withdrawn before enrolling any participants, so no results are available. Etonogestrel implants can cause side effects like irregular bleeding, mood changes, or weight gain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Started

Jul 2022

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Previous endometrial ablation * Pelvic pain and/or vaginal bleeding seeking treatment Exclusion Criteria: * Previous or current VTE * Liver tumour, benign or malignant, or active liver disease * Undiagnosed abnormal genital bleeding * Known or suspected breast cancer * Uncontrolled hypertension * Allergy to component of etonogestrel implant * Lack of patient consent

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Conditions

The condition(s) this trial relates to.

dysmenorrhea Metrorrhagia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abnormal uterine bleeding Dysmenorrhea

Contacts and locations

Locations

  • Saskatchewan Health Authority

    Regina, Saskatchewan, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.