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New MRI scan could help surgeons avoid facial nerve damage during brain tumor removal

NCT ID NCT04057976

Diagnosis Sponsor: King's College Hospital NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a special MRI technique called diffusion tensor tractography (DTT) to map the facial nerve before surgery for vestibular schwannoma, a benign brain tumor. The facial nerve is at risk during surgery, and injury can cause permanent facial weakness. The study involved 38 adults scheduled for surgery, who received an extra 10-minute MRI scan. Researchers compared the nerve position seen on the MRI with what surgeons found during the operation to see how accurate the technique was.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
probabilistic diffusion tensor tractography (DTT) MRI sequence
What this could lead to
If successful, this MRI technique could help surgeons see the facial nerve before operating, potentially reducing the chance of permanent facial weakness.
What could go wrong
This is a small, completed study with only 38 participants. The technique may not be reliable enough for routine use, and results need confirmation in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

38 people

The number who actually took part.

Started

Jun 2019

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The capacity to understand the patient information sheet and the ability to provide written informed consent * \>1.5cm extrameatal tumor determined to represent a vestibular schwannoma by preoperative imaging * HB grade I or II preoperatively Exclusion Criteria: * Patients not meeting the above inclusion criteria * Standard contraindications to MRI * Previous cranial radiotherapy or previous surgery to the cerebellopontine angle cistern or IAM

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Conditions

The condition(s) this trial relates to.

acoustic neuroma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Vestibular schwannoma

Contacts and locations

Locations

  • King's College Hospital NHS Foundation Trust

    London, London, SE5 9RS, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.