Can your eyes reveal MS severity? new study says yes
NCT ID NCT05661266
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether eye movements can help measure how severe multiple sclerosis (MS) is and how it affects thinking. 120 adults with MS had their eye movements tracked and compared to standard disability and cognitive tests. The goal was to build a database and train computer algorithms to identify reliable eye-based markers for MS.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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120 people
The number who actually took part.
- Started
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Aug 2023
- Finished
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Apr 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Our target sample size for the MS group is 120. Eligible patients with MS will be selected and categorized based on their EDSS score.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Able to provide informed consent. * Aged 18 years or older at the time of enrollment. * Able to read in either French or English. * Visual acuity of 20/100 in at least one eye (corrective glasses, contact lenses, surgery etc. are permitted) * Confirmed diagnosis of MS with no signs of progressive increase in physical disability within the past six months. * Neurological condition is medically stable during the study visit. Exclusion Criteria: * Evidence or medical history of psychiatric issues, which are known to also affect movements and oculomotor control. * Presence of comorbid neurological conditions to avoid eye movement anomaly confounds (Strabismus, cranial nerve palsy, stroke-causing hemianopsia). * Diagnosis of macular edema or other pre-existing ocular conditions that would prevent a participant from performing the eye movement assessments. * Recent (less than three months from enrollment) start of, change of dose, or irregular use of, new prescription drugs known to influence ocular motor visual function, such as benzodiazepines, antipsychotics and anticonvulsants. Occasional use of benzodiazepines for medical procedures is permitted, at the investigator's discretion, but should not occur within a short time period prior to or during an eye movement assessment * Diagnosis of Clinically Isolated Syndrome (CIS), Radiologically Isolated Syndrome (RIS) or Primary Progressive MS (PPMS). * Patients who are currently experiencing a relapse or who have experienced a relapse within the last three months. A relapse is defined as appearance of a new neurological abnormality or worsening of previously stable or improving pre-existing neurological abnormality, separated by at least 30 days from onset of a preceding clinical demyelinating event. The abnormality must have been present for at least 24 hours and occurred in the absence of fever (\< 37.5°C) or known infection. * Patients who have been undergoing disease-modifying therapy for less than three months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Genge Partners, Inc.
Montreal, Quebec, H4A 3T4, Canada
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