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Massive global study aims to prevent breathing tube removal disasters

NCT ID NCT06442930

Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 12 times

Summary

This study watches 3000 adults in hospitals worldwide to see what problems happen right after a breathing tube is removed. It looks for issues like very low oxygen, heart stopping, or needing to put the tube back in. The goal is to find better ways to keep patients safe during this common procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All adult patients (≥18 years old) undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU during the specified enrollment window (up to 4 weeks).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (≥18 years old) * Undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU * Undergoing extubation during the specified enrollment window Exclusion Criteria: * Patients will be excluded if the extubation is performed in the context of withdrawal of life support measures, * Patients will be excluded if the extubation is performed for tracheostomy decannulation For each patient who is not included, reasons for exclusion will be reported.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extubation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Amiri Hospital

    RECRUITING

    Kuwait City, Kuwait

  • Auckland City Hospital

    ACTIVE_NOT_RECRUITING

    Auckland, 1023, New Zealand

  • Austin Health - Austin Hospital

    ACTIVE_NOT_RECRUITING

    Melbourne, Victoria, 3084, Australia

  • Austin Health - Heidelberg Repatriation Hospital

    COMPLETED

    Melbourne, Victoria, 3079, Australia

  • Banner University Medical Centre

    COMPLETED

    Tucson, Arizona, 85724-5114, United States

  • Centre hospitalier de l'Université de Montréal (CHUM)

    COMPLETED

    Montreal, Quebec, H2X 0C1, Canada

  • Cork University Hospital

    COMPLETED

    Cork, T12 DFK4, Ireland

  • Eastern Health - Angliss Hospital

    COMPLETED

    Melbourne, Victoria, 3156, Australia

  • Eastern Health - Box Hill Hospital

    COMPLETED

    Melbourne, Victoria, 3128, Australia

  • Eastern Health - Maroondah Hospital

    COMPLETED

    Melbourne, Victoria, 3135, Australia

  • Freeman Hospital

    COMPLETED

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Galway University Hospitals

    COMPLETED

    Galway, H91 YR71, Ireland

  • Hospital Internacional de Colombia

    COMPLETED

    Piedecuesta, Colombia

  • Mater Misericordiae University Hospital

    COMPLETED

    Dublin, D07 R2WY, Ireland

  • Mayo University Hospital

    COMPLETED

    Castlebar, F23 H529, Ireland

  • Mount Sinai Hospital

    COMPLETED

    Toronto, Ontario, M5G 1X5, Canada

  • Niagara Health - Marotta Family Hospital

    COMPLETED

    Saint Catharines, Ontario, L2S 0A9, Canada

  • Oregon Health & Science University

    COMPLETED

    Portland, Oregon, 97239, United States

  • Rotorua Hospital

    COMPLETED

    Rotorua, 3010, New Zealand

  • Royal North Shore Hospital

    COMPLETED

    Sydney, New South Wales, 2065, Australia

  • Royal United Hospitals Bath

    COMPLETED

    Bath, BA1 3NG, United Kingdom

  • Southland Hospital

    COMPLETED

    Invercargill, 9812, New Zealand

  • St. Michael's Hospital

    COMPLETED

    Toronto, Ontario, M5B 1W8, Canada

  • Sunnybrook Hospital

    COMPLETED

    North York, Ontario, M4N 3M5, Canada

  • Surrey Memorial Hospital

    COMPLETED

    Surrey, British Columbia, V3V 1Z2, Canada

  • Tan Tock Seng Hospital

    COMPLETED

    Singapore, 308433, Singapore

  • The Moncton Hospital

    COMPLETED

    Moncton, New Brunswick, E1C 4B7, Canada

  • The Northern Hospital

    COMPLETED

    Melbourne, Victoria, 3076, Australia

  • The University of Chicago

    COMPLETED

    Chicago, Illinois, 60637, United States

  • The University of Texas Health Science Center

    COMPLETED

    Houston, Texas, 77030, United States

  • University Health Network - Toronto General Hospital

    RECRUITING

    Toronto, Ontario, M5G 2C4, Canada

  • University Health Network - Toronto Western Hospital

    COMPLETED

    Toronto, Ontario, M5T 2S8, Canada

  • University Hospital Waterford

    NOT_YET_RECRUITING

    Waterford, X91 ER8E, Ireland

  • University of Arkansas for Medical Sciences

    COMPLETED

    Little Rock, Arkansas, 72205, United States

  • University of Florida

    COMPLETED

    Gainesville, Florida, 32608, United States

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