Breath of life: exhaled gas may reveal ICU outcomes
NCT ID NCT07454057
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will measure exhaled carbon monoxide daily in 220 ICU patients to see if changes in this gas are linked to survival and recovery. It is purely observational, meaning no treatment is given. The goal is to learn whether this simple breath test can help doctors predict complications like kidney injury or longer hospital stays.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 220 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adult intensive care unit (ICU) patients (≥18 years) admitted to the study site will be screened consecutively. Eligible participants are those expected to remain in the ICU for at least 48 hours and able to complete daily exhaled carbon monoxide (eCO) measurements (spontaneously breathing or mechanically ventilated). Written informed consent will be obtained from the patient or a legally authorized representative. Patients meeting any exclusion criteria (e.g., carbon monoxide poisoning, active smoking within 24 hours, inability to perform breath sampling, pregnancy/breastfeeding, hereditary hemoglobinopathies) will not be enrolled. Participants may be withdrawn if informed consent is revoked, if continued data collection is judged clinically inappropriate, if the patient is transferred and lost to follow-up, or if eCO data are missing for more than 50% of the 7-day collection period (fewer than 4 valid measurements).
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥ 18 years 2. Admitted to the intensive care unit (ICU) at the study site 3. Expected ICU length of stay ≥ 48 hours 4. Able to complete exhaled carbon monoxide (eCO) measurement (spontaneously breathing or mechanically ventilated) 5. Written informed consent provided by the patient or a legally authorized representative Exclusion Criteria: 1. Carbon monoxide poisoning 2. Active smoking within 24 hours prior to ICU admission 3. Unable to perform breath sampling (e.g., massive airway bleeding, severe airway obstruction, extracorporeal membrane oxygenation) 4. Ineffective sampling due to poor mask seal or special ventilation modes 5. Pregnant or breastfeeding 6. Known hereditary hemoglobinopathies (e.g., sickle cell disease, thalassemia) 7. Patient or family refusal 8. Other conditions deemed unsuitable by investigators
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.