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Can light exercise with blood flow cuffs boost heart failure recovery?

NCT ID NCT07627737

Symptom relief Sponsor: Biruni University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two types of exercise—aerobic and resistance—both combined with blood flow restriction (using cuffs on the legs) in 40 people with stable heart failure. The goal is to see which approach better improves muscle oxygen levels, heart stress markers, daily function, and quality of life over 8 weeks. Researchers hope to find a safe, low-cost rehab option that works even for patients with limited exercise tolerance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exercise with blood flow restriction (aerobic or resistance training)
What this could lead to
If successful, this could point toward a short, low-cost rehab program that helps heart failure patients exercise more effectively and feel better.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. The exercises involve blood flow restriction, which carries risks like bruising or discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * NYHA functional class I-III, * HFrEF and/or HFmrEF with left ventricular ejection fraction \<50%, * functional capacity that does not prevent participation in exercise, and * clinical stability within the last 3 months. Exclusion Criteria: * history of acute coronary syndrome or revascularization within the last 12 months, * uncontrolled hypertension, defined as ≥180/≥110 mmHg or 160-179/100--109 mmHg despite treatment, or uncontrolled arrhythmia, * conditions contraindicating the application of blood flow restriction training, such as significant peripheral arterial disease or atherosclerosis obliterans, * severe orthopedic or neurological limitations that would prevent exercise, * presence of atrial fibrillation or a pacemaker, * severe liver disease, * impaired renal function, defined as eGFR \<30 mL/min, * peripheral neuropathy, * dialysis, * moderate to severe valvular disease, * moderate to severe COPD, * hospitalization due to cardiovascular causes within the last 30 days, * intracranial aneurysm, arteriovenous malformation, cerebral neoplasm, or abscess, * angina pectoris and use of medications known to affect ischemic conditioning/occlusion, such as cyclosporine or glibenclamide, * use of dual antiplatelet therapy or anticoagulants, including NOACs, low-molecular-weight heparin, or vitamin K antagonists.

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Biruni University

    Istanbul, Zeytinburnu, 34015, Turkey (Türkiye)

    Contact Email: •••••@•••••

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