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Brain zaps during workouts may unlock pain relief secrets

NCT ID NCT07212829

Knowledge-focused Sponsor: Vrije Universiteit Brussel Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why exercise often makes pain and fatigue worse for people with chronic widespread pain or fibromyalgia. Researchers will test if applying a mild electrical current to the brain (tDCS) during exercise can change how pain-related genes work. 120 participants (60 with chronic pain and 60 healthy) will exercise with either real or fake tDCS to see how it affects pain, fatigue, and genetic markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS)
What this could lead to
If successful, this could reveal why exercise worsens pain in some people and point to ways to prevent that, potentially improving exercise tolerance.
What could go wrong
This is an early-stage mechanistic study, not a treatment trial. Results may not lead to a direct therapy, and individual responses to tDCS can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients Participants in the patient group must meet all of the following criteria: 1. Diagnosis of chronic widespread pain (CWP) or fibromyalgia; 2. Age between 18 and 70 years old; 3. Body mass index (BMI) ≤ 35; 4. Widespread Pain Index (WPI) assessment: the WPI questionnaire (0-19 points) will be used to record the number and distribution of painful body sites. Participants will be classified as having CWP if pain is reported on both sides of the body, above and below the waist, and in the axial skeleton, with pain symptoms lasting ≥ 3 months; 5. Stable medication use for at least 1 month prior to study entry. Healthy control group Participants in the healthy control group must meet all of the following criteria: 1. Age between 18 and 70 years old; 2. Body mass index (BMI) ≤ 35; 3. No chronic conditions, such as chronic pain and diabetes. Exclusion Criteria: For both patients and healthy controls, participants will be excluded if they meet any of the following: 1. Current pregnancy or pregnancy within the past 12 months; 2. Contraindications for non-invasive brain stimulation (NIBS), in line with published safety guidelines; 3. History of neurological disorders, including epilepsy (personal or family history), traumatic brain injury, stroke, dementia, or Parkinson's disease; 4. Major medical conditions, including cancer, endocrine or metabolic disorders, urine, genital and cardiovascu-lar diseases (e.g., myocardial infarction, heart failure, arrhythmia, uncontrolled hypertension). 5. Substance abuse. 6. Presence of psychiatric disorders other than depression or anxiety.

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Conditions

The condition(s) this trial relates to.

Chronic Pain fibromyalgia Motor Activity Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic widespread pain Fibromyalgia (FM)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • VUB

    RECRUITING

    Jette, 1090, Belgium

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