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Can exercise rewire how we feel pain? study tests intensity levels

NCT ID NCT06207422

Knowledge-focused Sponsor: University Ghent Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how two different exercise programs—moderate and high intensity—affect the way the brain processes pain in healthy, sedentary adults. Researchers measured pain sensitivity and the body's natural pain modulation systems before and after a 10-week training period. The goal was to find the best exercise prescription for improving pain processing, which could later be tested in people with chronic pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise training programs (moderate and high intensity)
What this could lead to
If successful, this could provide a basis for using specific exercise programs to improve pain processing in people with chronic pain.
What could go wrong
This is a small, early-stage study in healthy individuals, so results may not apply to chronic pain patients. The trial was terminated, limiting data.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Nov 2023

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age between 18 and 55 years * BMI between 20 and 25 kg/m² * Dutch-speaking * sedentary job and performing less than 3 hours of moderate physical activity per week Exclusion Criteria: * current pain complaints or other (medical and/or psychological) health problems * history of serious pain complaints or (medical and/or psychological) health problems * history of serious conditions (e.g. cancer, cardiovascular disease, epilepsy, diabetes, depression, etc.) * being pregnant * pregnant in the past 12 months * currently breastfeeding

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • Ghent University

    Ghent, 9000, Belgium

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