Fasted exercise: boon or bust for brain and body?
NCT ID NCT05919979
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looked at how doing high-intensity exercise while fasting for 24-34 hours changes energy use and thinking skills in 25 healthy adults. Participants either rested or exercised during the fast, and researchers measured things like breathing, blood sugar, and cognitive tests. The goal is to better understand how fasting and exercise work together.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- high-intensity exercise during fasting
- What this could lead to
- If successful, this could help clarify how exercise during fasting affects metabolism and brain function, potentially guiding future health recommendations.
- What could go wrong
- This is a very small pilot study (25 people) in healthy adults, so results may not apply to the general population or lead to any immediate practical advice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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25 people
The number who actually took part.
- Started
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May 2023
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18-40 years old. * Body mass index: 18.5-30.0 Kg/m2. * Stable body weight (5kg range within the last 3 months) * Being able to consume all the food items provided as part of the study. * Not having change the time zone or have shifted sleeping hours equivalent to more than 3 hours on the previous 2 weeks. Exclusion Criteria: * Diagnosed with any chronic condition that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise. * Diagnosed with a chronic endocrine, digestive, rheumatic, neurological, cardiac, pulmonary, autoimmune, or infectious condition that affects energy metabolism. * Presenting any signs or symptoms of illness that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise. * Pregnant or breastfeeding. * Using medications or supplements that may alter energy metabolism. * Currently undergoing or having undergone any type of nutritional intervention or treatment in the past 3 months. * Engaging in more than 5 hours per week of habitual moderate-to-vigorous cycling. * Any other condition that, in the research team's opinion, discourages participation in the study.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Instiuto Mixto Universitario Deporte y Salud
Granada, Granada, 18007, Spain
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