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Exercise plus brain stimulation shows promise for memory loss

NCT ID NCT03670615

Symptom relief Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether combining exercise with a gentle brain stimulation technique called tDCS can improve memory in 60 older adults with mild cognitive impairment or Alzheimer's disease. Participants exercised and received either real or sham tDCS. The goal was to see if the combo helps recognition and recall memory. Results are still being analyzed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS) and exercise
What this could lead to
If it works, this could point toward a non-drug way to ease memory problems in early Alzheimer's or mild cognitive impairment.
What could go wrong
This is a small pilot study (60 people) with no phase, so results are very early. The memory benefits may be small or not last, and tDCS can cause mild scalp discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Nov 2018

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males or females ≥50 years of age * DSM-5 criteria for major or mild neurocognitive disorder due to AD or mixed AD/vascular disease * Mild severity of impairment (standardized Mini-Mental State Examination (MMSE) score ≥19) * Read and communicate in English Exclusion Criteria: * Change in cognitive enhancing medications (ChEIs and/or memantine) less than 3 months prior to study screen * Change in anticonvulsants or psychotropic medications less than 1 month prior to study screen * Currently taking benzodiazepines * Presence of metal implants that would preclude safe use of tDCS (e.g. pace-maker) * Significant neurological condition (e.g. epilepsy, Parkinson's disease, multiple sclerosis) * Current psychiatric disorders (e.g. schizophrenia, bipolar disorder, depression, psychosis) or current substance use disorder * Medical contraindications to increasing activity level according to the Canadian Society of Exercise Physiology Questionnaire

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease Mild cognitive impairment

Contacts and locations

Locations

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M3H0A7, Canada

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